Where does hope come from

Heisenberg's first paper on quantum mechanics was one of the most profound scientific achievements of all time. Subatomic world is so small, so far away from our concrete experience. How can he formulate a coherent mathematical theory about the subatomic world? 

In the first paragraph of his paper, he used the word hope twice. In the second paragraph, he stated, "it seems sensible to discard all hope ..." Then he started to present his new ideas. 

When we are hopeless, don't despair. Hope comes from hopeless. A great dawn is waiting for us tomorrow.