设万维读者为首页 广告服务 技术服务 联系我们 关于万维
简体 繁体 手机版
分类广告
版主:阿飞的剑
万维读者网 > 茗香茶语 > 跟帖
插入事件是:多种自然发生的重组事件?
送交者: gooddday 2020月03月29日21:57:40 于 [茗香茶语] 发送悄悄话
回  答: 股沟了一下 看到这个,这里是不是也是说插入是自然突变成分多? gooddday 于 2020-03-29 21:34:48

The unprecedented epidemic of pneumonia caused by a novel coronavirus, HCoV-19, in China and beyond has caused public health concern at a global scale. Although bats are regarded as the most likely natural hosts for HCoV-191,2 , the origins of the virus remain unclear. Here, we report a novel bat-derived coronavirus, denoted RmYN02, identified from a metagenomics analysis of samples from 227 bats collected from Yunnan Province in China between May and October, 2019. RmYN02 shared 93.3% nucleotide identity with HCoV-19 at the scale of the complete virus genome and 97.2% identity in the 1ab gene in which it was the closest relative of HCoV-19. In contrast, RmYN02 showed low sequence identity (61.3%) to HCoV-19 in the receptor binding domain (RBD) and might not bind to angiotensin converting enzyme 2 (ACE2). Critically, however, and in a similar manner to HCoV-19, RmYN02 was characterized by the insertion of multiple amino acids at the junction site of the
author/funder.   is the S1 and S2 subunits of the Spike (S) protein. This provides strong evidence that such insertion events can occur in nature. Together, these data suggest that HCoV-19 originated from multiple naturally occurring recombination events among those viruses present in bats and other wildlife species. 

谷歌翻译:

在中国及其他地区,由新型冠状病毒HCoV-19引起的史无前例的肺炎流行已引起全球公众的关注。尽管蝙蝠被认为是HCoV-191,2最有可能的自然宿主,但病毒的起源仍不清楚。在这里,我们报告了一种新的蝙蝠衍生冠状病毒,称为RmYN02,它是通过对2019年5月至10月间从中国云南省收集的227只蝙蝠的样本进行宏基因组分析而鉴定的.RmYN02与HCoV-19在该规模上具有93.3%的核苷酸同一性在完整的病毒基因组中具有17.2个基因的97.2%的同一性,其中它是HCoV-19的最亲近的亲戚。相反,RmYN02在受体结合域(RBD)中与HCoV-19的序列同一性较低(61.3%),并且可能不与血管紧张素转化酶2(ACE2)结合。然而,至关重要的是,与HCoV-19相似,RmYN02的特征是在HcoV-19的连接位点插入了多个氨基酸。作者/ funder。是Spike(S)蛋白的S1和S2亚基。这提供了强有力的证据,证明这种插入事件可以自然发生。总之,这些数据表明,HCoV-19源自蝙蝠和其他野生生物中存在的那些病毒中的多种自然发生的重组事件。


0%(0)
0%(0)
标  题 (必选项):
内  容 (选填项):
实用资讯
北美最全的折扣机票网站
贝佳药业美国专利【骨精华】消关节痛、骨刺、五十肩【心血通】改善心绞痛

一周点击热帖 更多>>
一周回复热帖
历史上的今天:回复热帖
2019: 茶馆成了解放天性放飞自我的地方。有意
2019: 周末附加题:国画的散点透视比西画的单
2018: 美国正在将中俄推向更强的联盟
2018: 中国的死敌:日本和俄罗斯。一个杀中国
2017: 来,给我亲耐的老战友臭葫芦一点丫弹熏
2017: 扣扣说邓丽君不咋地,这不是造十三亿中
2016: 苏小白:谈写作
2016: 两座火山
2015: 米粉就是比面条好吃
2015: 宽容一个尿急的三岁小孩和鼓吹当街大小