这一文，迟到了38个小时！

    为什么呢？因为自8月12日凌晨始，无数次点击

      “ 发表 ”，界面瞬间变白版，只留下一行:

        什么意思 ？ 什么叫 SQLI ATTACK ?

 什么是SQL病毒注射式攻击（SQLI）及如何防止它？

   2017年10大文档中将SQLI注射式攻击

   列为Web应用程序安全性的第一号威胁！

  来源链接：

https://www.acunetix.com/websitesecurity/sql-injection/

这就是毒害全人类213个国家和地区 感染2000多万人

杀死748,572人的2019新型冠状病毒的毒株骨干来源

—— 浙江舟山蝙蝠冠状病毒  ZXC21 & ZC45

SARS coronavirus (SARS-CoV), the causative agent of the large SARS outbreak in 2003, originated in bats. Many SARS-like coronaviruses (SL-CoVs) have been detected in bats, particularly those that reside in China, Europe, and Africa. To further understand the evolutionary relationship between SARS-CoV and its reservoirs, 334 bats were collected from Zhoushan city, Zhejiang province, China, between 2015 and 2017. PCR amplification of the conserved coronaviral protein RdRp detected coronaviruses in 26.65% of bats belonging to this region, and this number was influenced by seasonal changes. Full genomic analyses of the two new SL-CoVs from Zhoushan (ZXC21 and ZC45) showed that their genomes were 29,732 nucleotides (nt) and 29,802 nt in length, respectively, with 13 open reading frames (ORFs). These results revealed 81% shared nucleotide identity with human/civet SARS CoVs, which was more distant than that observed previously for bat SL-CoVs in China. Importantly, using pathogenic tests, we found that the virus can reproduce and cause disease in suckling rats, and further studies showed that the virus-like particles can be observed in the brains of suckling rats by electron microscopy. Thus, this study increased our understanding of the genetic diversity of the SL-CoVs carried by bats and also provided a new perspective to study the possibility of cross-species transmission of SL-CoVs using suckling rats as an animal model.

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Introduction

Coronaviruses (CoVs) are a family of RNA viruses belonging to the Coronaviridae family and the Coronavirinae subfamily and are the largest group of positive-sense single-stranded RNA viruses. From an academic perspective, CoV can be divided into four genera, namely Alphacoronaviruses, Betacoronaviruses, Gammacoronaviruses, and Deltacoronaviruses. The  alphacoronaviruses and betacoronaviruses are usually found in mammals, while the gammacoronaviruses and deltacoronaviruses are mainly associated with birds1,2. SARS-CoV is the causative agent of the severe acute respiratory syndrome (SARS) outbreak that occurred in 2002–2003. This SARS outbreak was the first human pandemic to break out since the beginning of the 21st century, and it resulted in nearly 8000 cases of infection and 800 deaths worldwide3,4. SARS-CoV belongs to the Betacoronavirus genus, and its genomic sequence exhibits low levels of similarity with the previously identified human CoVs-OC43 and 229E. Thus, we hypothesized that SARS-CoV underwent a long and independent evolutionary process. The SARS-CoV genome usually encodes four structural proteins: the spike protein (S), envelope protein (E), membrane protein (M), and nucleocapsid protein (N). Among them, the S protein is a trimeric, cell-surface glycoprotein that consists of two subunits (S1 and S2), whereas the S1 subunit is responsible for receptor binding. Variations in the S protein, to a large extent, are responsible for the tissue tropism and host ranges of different CoVs5,6.

https://www.ncbi.nlm.nih.gov/

pmc/articles/PMC6135831/

https://twitter.com/GlobalHimalaya/status/1293343480261959681