Humans and germs: A systematic analysis |
送交者: jingchen 2021年11月07日11:40:49 於 [健康生活] 發送悄悄話 |
Humans and germs: A systematic analysis
The novel coronavirus pandemics has been around for some time. Most of the time, we deal with the viruses in an ad hoc manner. We would like to study the interactions between human societies and germs in a systematic way. This is help us understand the long term consequences of our responses to germs.
The economy of RNA life
Human beings as part of the ecosystem
From the ecosystem perspective, our war against microbes is futile over long term. But microbes are not our biggest threat. Any society with below replacement fertility is doomed. The biggest threat to our society is the below replacement fertility. What is the cause for such a low fertility? There can be several reasons. One could be the overdrive of our immune systems in a sterile environment. When our immune systems face less external invaders, they often turn to our own cells. This could be the reason more auto immune diseases occur in clean environment. Women’s immune systems could also attack the cells of fetuses. There are evidences that the existence of some parasites is correlated to higher fertility rate. In a society which could not reproduce itself, measures curbing the spread of microbes may further depress fertility rate. This will further deteriorate demographic structure of a society.
Demographics and Pandemics
Novel coronavirus pandemics has spread all over the world. While few communities are spared of this scourge, communities with aging demographics are hardest hit. Younger communities are less devastated by the advance of this disease. Why demographics makes such a great difference in the face of pandemics? The existence of microbes is not the sole reason for pandemics. Microbes have existed for billions of years. Sometimes they cause pandemics. Sometimes they don’t. They may cause pandemics in some populations. They may not cause pandemics in other populations. The occurrence and spread of pandemics are the result of interactions of the whole ecosystem. Specifically, there can be several reasons. First, older people generally have weaker immune systems. In a population with higher percentage of older people, more people are likely to get sick from the spread of microbes. Second, with the aging of general population, the work force is aging as well. Many people work to the age of sixty five and beyond. The advent of any disturbance will stress the senior work force more and compromise their ability to carry on the routines. Third, the medical system and other service systems are already stretched thin even in normal times in an aging society. There is little spare capacity to cushion the extra burden. Furthermore, the arrival of a pandemics often significantly reduces the capacity of the social system. The impact of microbe invasion, or other disturbances, are much more pronounced in an aging society than in a young society. In most of the Western societies, the birthrate has dropped below the replacement rate for several decades. Yet the policymakers pay scant attention to this vital indicator. To them, the financial markets are the leading indicator of the society. They take many measures to pop up the financial market, most of which further depress the birthrate. In Canada, pension deduction rate has been increasing continuously over time. This infuses more money into the financial market but reduces the amount of money to support young families at their most fertile period. In US, low interest rate and quantitative easing fuels the longest bull market in history. The same policies also dilute the resources to ordinary families. The birthrate in US has dropped to the lowest level in record. Our society is not supported by the stock market. Our society is supported by food, electricity and fuels. Our society is supported by grocery stores cashiers and stockers, farmers and workers. This becomes plain and simple during crisis. We need more people, more young people with strong immune systems, more young people who can work effectively under stress. To achieve a younger demographics, we can’t keep our eyes glued to the financial indicators. We have to pay attention to birthrate and other vital biophysical indicators. This is the first step we need to take.
Natural vaccines In times of pandemics, many of us look for vaccines to keep us safe again. What are the properties of vaccines? Vaccines should be similar enough to original pathogens. They should induce our bodies to generate immune responses that are effective on original pathogens. Vaccines should be dissimilar enough to original pathogens. They should not be as pathogenic as the original pathogens. Researchers work hard in their labs to mutate the original pathogens in a proper way, with proper amount to generate the desired vaccines. Nature is a gigantic lab. Mutations occur everywhere, all the time. Every pathogen has many siblings, cousins and offspring. They are the natural candidates for vaccines. The very first vaccine, a cow vaccine for smallpox, was a natural vaccine from cows. Even new vaccines are often speed up natural vaccines. Researchers inject pathogens into chicken bodies, hoping to induce the desired mutations from the interactions between pathogens and chickens. Do we really have to wait for the lab vaccine? Among people never exposed to novel coronavirus, 40% to 60% have the same kind of T cells (a type of immune cells) as those exposed to novel coronaviruses. Coronaviruses are a big family with many cousins. Some common cold are caused by coronaviruses. Probably many of us already got vaccinated by those cousin coronaviruses. Those natural vaccines may not be effective enough. That may be true. But artificial vaccines may not be effective enough either. There is no guarantee that artificial vaccines are more effective than natural vaccines. There is guarantee that natural vaccines offer broader spectrum protection than artificial vaccines. To gain broad natural vaccine, it is important not to over sterilize our environment. Nature is not our enemy. Nature is our sanctuary, spiritually and physically. It gives us vaccines. It gives us vitality.
Shall we immunize for every disease?
When we install an app in a computer, it will help run a program smoothly. But we don’t install every app in a computer. Every app will take up some space, clog the system a little bit and slow down the running of the computer somewhat. If we don’t use a program often, we usually rely on the generic browser to perform the task, although it can be less efficient.
Human beings have two set of immune systems, the innate immune system and adaptive immune system. When we get older, we get exposed to more pathogens. Our adaptive immune system gets trained and stronger. With each exposure to new pathogens, our adaptive immune system develops new types of antibodies specifically targeted to that pathogens. But each new antibodies take up some space, clog the system a little bit and slow down the running of the system somewhat. When we get older, our innate immune system, as well as our most other systems, get weaker. It is probably not wise to load all the possible vaccines we can imagine and exhaust the capacity of our bodies.
How to choose which vaccine we should receive? Our bodies are the embodiment of four billion year’s of evolutionary wisdom. They give clues. If a type of antigens poses serious threat to our health, the corresponding antibodies, once generated, often last for a lifetime. For example, smallpox antibodies will last for a lifetime. If some antibodies get weaker or disappear completely soon after generation, it suggests that our bodies don’t regard the corresponding antigens as serious health threat. Our bodies don’t think the benefits of such antibodies justify their costs.
Antibodies against novo coronaviruses usually don’t last very long. Some people who got infected with the viruses will soon be reinfected by the same or similar types of viruses. This suggests that our bodies don’t regard these viruses as serious enough to justify long term antibodies.
Our bodies are not foolproof. Nothing is foolproof. Some suggest that novo coronaviruses could be originated in lab. Our bodies are especially prone to mistakes when dealing with novel creations. This also suggests that it is extremely important to find out the origin of novo coronaviruses. Unfortunately, the majority in the scientific community, out of self interest, are highly hostile to any effort to uncover the truth.
Shall we immunize for novo coronaviruses?
Action or inaction
The wisdom of the body: Immune Systems
Our bodies are the distilled wisdom of four billion years of natural selection. With fierce competition for survival, our bodies become very efficient. There is not much redundancy. The fact that we get sick from time to time indicates that there is indeed not much redundancy in our immune systems.
Our immune systems are comprised of innate systems and adaptive systems. Innate systems are our broad spectrum protectors. Adaptive systems are our specialized protectors calibrated to the specific environment we grow up with. When we grow up, our adaptive systems become stronger. At the same time, our innate systems become weaker. When we expand adaptive systems, we squeeze innate systems. To retain the capacity of our innate systems as much as possible, our bodies often reduce the capacity of those adaptive systems if certain pathogens don't pose great threat to our health. For example, soon after we get vaccine shots for novo coronaviruses, the antibody levels in our bodies start to decline significantly. This suggests that our bodies don't give high priority to adaptive system against coronaviruses.
Novo coronaviruses mainly cause harm to old people. Few children and young people get seriously sick from this type of viruses. Children have strong innate immune systems and weak adaptive immune systems. Older people have weaker innate immune systems and stronger adaptive immune systems. This suggests that innate immune systems are important in fighting off coronaviruses. If so, we should concentrate on improving our innate immune systems, by exercising, relaxing and better foods. Vaccines stimulate and strengthen the adaptive immune systems. While it is helpful to stimulate adaptive immune systems, more of adaptive systems might crowd out innate systems and other parts of the adaptive systems. If we insist on injecting large doses of coronavirus vaccine into our body, this may squeeze the capacity of our immune systems that are responsible for more serious diseases, such as cancer.
Our bodies are the distilled wisdom of four billion years of natural selection. Much of modern science, such as coronavirus vaccines, is hastily assembled in several years. The crow, the crown and the crowd assert that modern science should tramp over our ancient wisdom. However, modern science can benefit greatly from our ancient wisdom, if we are humble enough to learn.
How do mRNA vaccines work?
All medicines have side effects. When we decide to use a medicine, we need to study whether the benefits of a medicine outweighs its costs. We often leave the job to experts. However, experts are not impartial. Experts benefit from the growth of the industry. They consciously or subconsciously exaggerate the benefits and downplay the potential harms of medicines. We all know heroin, an addictive drug. How was this drug named? When it was first brough to the markets, producers of this drug thought it had so many benefits with so little harmful side effects. They call it heroin, a heroic drug. Now people know its long term impacts. You might say it is an isolated incident. But it is not. In the past several decades, Purdue Pharma, owned by the Sackler family, marketed OxyContin, a highly addictive drug, to many people. The lives of millions of people have been destroyed. In the process, the medical community actively pushed for the use of the drug. They benefit from the increase of dependant people, who are dependable clients. The media community and the whole elite community stand largely silent. They become more influential when more people need help. Only those addicted and their families and friends push to end the distribution of the drug.
This time, the majority of vaccines are mRNA vaccine, a new type of vaccine. We will discuss the mechanism of the mRNA vaccine. One dose of mRNA vaccine contains about 40 trillion mRNA molecules. After the injection of the vaccine, these mRNA molecules will enter your cells, command your cells to make spike proteins that are same as from the coronavirus and release them from the cells. When these spike proteins are outside of the cells, they encounter immune cells, which recognize the spike proteins as foreign invaders. Our immune system produces antibodies to attack spike proteins, clamping different spike proteins together, to be destroyed by other immune cells. Some spike proteins are attached to cells. Our immune systems will attack these cells as foreign cells.
Trillions of mRNA molecules will make our cells to produce trillions of spike proteins. These spike proteins will saturate many parts of our bodies, especially capillary blood vessels. When antibodies encounter these spike proteins, they clamp these spike proteins together. This will clot many of the capillary blood vessels, which are tiny. The reduced blood supply will reduce the ability of all organs and weaken our overall health, short term and long term. There are many studies about the very harmful impacts of the vaccines. Unfortunately, there is scant reporting in the mainstream media.
These novel corona viruses cause little damage to young people in general. However, the vaccines often cause quite big harm, especially to young men. Many heart diseases have been reported after the injection. Now FDA requires the manufactures to put up warning on the labels of vaccines. We should investigate the effects of the vaccines carefully before making a decision on a shot. It is not just a simple shot. It has already ruined the lives of many people.
Is it healthy to sterilize our environment too much?
Consensus is not equal to truth
Since the outbreak of novel coronavirus disease, tremendous amount of research has been done on the virus. However, few researchers are working on the fundamental problem of the origin of the viruses. Instead, there is already a consensus in the research community: The virus is not lab related.
Why are there so few researchers working on the origin of the virus? The origin of the virus is an extremely important problem, both scientifically and for the public health. Scientifically, the origin of a new species or a new type of type is poorly understood. To pinpoint the origin will help understand the mechanism of the emergence of a new type of life and study the process of evolution. It is of great scientific value. For the public health, to understand the origin and process of evolution of viruses will help us prevent or detect early future outbreaks of pandemics. Why are there so few researchers to undertake such an important task?
Why is there such a strong consensus about the origin of the virus, when so little is known? Researchers have a strong consensus because they have a strong common interest. If the novel coronaviruses are found out to be lab related, the reputation of not only one research lab, but also the whole research community will be tarnished. As a result, there will be tighter regulation and less funding in the future. Many careers in the research community of the microbes will be destroyed. Because of the strong common interest of the research community, there is a strong consensus from the research community.
There are many consensuses in religions. The founders of various religions often claim they have encountered angels. These stories are not the truth. But they are religious truth. Anyone questioning the truthfulness of their stories constitutes blasphemy. Increasingly, scientific work is conducted by the coercion of consensus, not by the search and research for the truth. Many theories are not the truth. But they are scientific truth. Anyone questioning the truthfulness of their stories are anti scientific. Increasingly, facts are not important in public discussion. You don’t need to be factually correct. But you have to be politically correct.
Evidence in Scientific Research
Concluding remarks
When the novel coronaviruses were spreading rapidly, it is natural to take hasty steps to stop their advance. With time, we should sit back to access the real danger. Over long term, the demographic trend in our societies pose far greater threat. Population aging is caused by the structure of our social systems. The danger of an aging society becomes very clear during pandemics. This may provide us an opportunity to reflect on and reform our social systems, which is very difficult in other time.
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