It is common knowledge that the ocular bioavailability of drugs applied topically as eye-drops is very poor. The absorption of drugs in the eye is severely limited by some protective mechanisms that ensure the proper functioning of the eye, and by other concomitant factors, for example:
• Drainage of the instilled solutions;
• Lacrimation and tear turnover;
• Metabolism;
• Tear evaporation;
• Non-productive absorption/adsorption;
• Limited corneal area and poor corneal permeability; and
• Binding by the lacrimal proteins.
http://www.pharmatutor.org/articles/review-on-ocular-drug-delivery?page=0,3
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