用進化前提來指導得出如下學說:超保留基因歷經滄桑地從老鼠保留到了人,那麼一定有什麼特別重要的功能,被自然選擇下來無法變異。
The paper in question focuses on segments of 'ultraconserved' DNA — sections that have stayed exactly the same throughout recent vertebrate evolution, and are identical in humans, rats and mice (see page 10). The available evidence suggests that this extreme example of DNA conservation is no accident: the sequence stays because there is a strong selective force weeding out mutations in it. In other words, it is likely to be important to its host.
結果,試驗結果出乎意料:去掉該基因段的老鼠,吃喝拉薩生殖都毫無問題。
Yet when researchers based at Lawrence Berkeley National Laboratory in California removed four pieces of ultraconserved DNA from different mice, it had absolutely no effect on the rodents (N. Ahituv et al. PLoS Biol. 5, e234; 2007). This counterintuitive result contradicts predictions based on genetic conservation and the shaping of our genomes during evolution.
自然Nature 449, 1 (6 September 2007)最新編輯的。
我在想,如果用創造前提來指導試驗,那麼關於這些超保留基因的功能應該有什麼樣設想呢?