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什麼叫“懂科學”
送交者: nile 2010年11月10日18:38:28 於 [教育學術] 發送悄悄話

“你懂不懂科學?”。這可以成為一個問題嗎?如果你懂科學,你懂不懂文化?懂不懂語言?“科學”是一個概念。既然是概念就有內涵和外延。科學的內涵說明它區別於其他事物的基本特徵或屬性,也就是科學的定義。科學的外延是具有這一屬性的一切事物。沒有人不能理解科學的內涵,同時也沒有人能夠理解科學的全部外延。所以問出這問題的人一定是白痴。

這人就是痞夫(pifu01),。“痞夫”除了問這個白痴問題,還問了一個有點水平的問題:誰證實過肖傳國的結果。不過“痞夫”緊接着問“你?”又把他那點水平倒進了陰溝。

肖的結果當然有人重複過,如果他有基本的文獻檢索能力應該容易就知道這個事實。nile給他出示了一篇綜述後面的參考文獻。稍有一點科學素質的人應該知道綜述都是對某個領域裡多位作者的工作的論述。其中必然有這項工作的背景,現狀和展望。以下就是這篇綜述的作者引述的Ruggeri M等用前角神經轉移控制膀胱的工作。

The ability to repair immediately transected ventral roots (VRs) was tested in 10 dogs [10]. The subjects were tested   at 78 and 373 days postoperatively for bladder contraction induced by functional electrical stimulation. At 78 days,  no increase in bladder pressure could be obtained via electrical stimulation. However, at 373 days, five of eight  nimals had a functional electrical stimulation-induced bladder contraction. The average increase in bladder pressure was 9.0±3.3 cm H20. Three weeks before the animals were euthanized, four injections of 4% fluorogold were made lateral to each ureteral orifice. Lumbar and sacral spinal cord segments were obtained postmortem and used to  measure the quantity of fluorogold retrogradely labeled motor neurons. All 10 experimental animals were found to have fluorogold-labeled neuronal cell bodies in the lateral ventral horns and in the zona intermedia of upper sacral spinal segments. This confirmed that despite variability in functional outcomes, there is regrowth of motor axons to the bladder [10]. This theory was further tested by immediately grafting the genitofemoral (GF) nerve, intercostal nerves, or coccygeal (CG) roots to transected bladder sacral roots [11]. Of the four GF nerve transfers, only one  could generate bladder pressure with electrical stimulation. This occurred on postoperative day 96. For the three CG root nerve transfers, one generated a pressure on postoperative day 178. No statistical significance was noted  between the three groups (sham, GF, CG) with regard to total number of fluorogold-labeled cells. One interesting point was that the fluorogold-labeled neurons contributed to different areas of the spinal cord. The shamoperated

animals had a significant number in the sacral cord region, the CG animals in the coccygeal cord segments, and the GF had a larger number in the lumbar cord. In a similar but larger study of 10 animals, 3 GF were able to generate a bladder pressure with electrical stimulation [12].

10. Ruggeri M, Braverman A, DAndrea L, et al.: Functional reinnervation of the canine bladder after spinal root transaction and immediate end-on-end repair. J Neurotrauma 2006, 23:11251136.

11. Ruggeri M, Braverman A, DAndrea L, et al.: Functionalreinnervation of the canine bladder after spinal root transaction and immediate somatic nerve transfer. J Neurotrauma 2008, 25:214224.

12. Ruggeri M, Braverman A, DAndrea L, et al.: Functional reinnervation of the canine bladder after spinal root transaction and genitofemoral nerve transfer at one and three months after denervation.J Neurotraum 2008, 25:401409.

還有中國作者得出了與肖傳國同樣的結果:

Reconstructed bladder innervation below the level of spinal cord injury: the knee-tendon to bladder artificial reflex arc

XY Zheng, CL Hou, HB Zhong, RS Xu… - The Journal of Spinal …, 2009 - ncbi.nlm.nih.gov

Bypassing Spinal Cord Injury: Surgical Reconstruction of Afferent and Efferent Pathways to the Urinary Bladder after Conus Medullaris Injury in a Rat Model

H Lin, C Hou… - Journal of reconstructive microsurgery, 2008 - thieme-connect.com


如果“痞夫”無法理解任何一個學科的發展都需要建立在前人的工作積累基礎上,他問nile“你懂不懂科學”也就不難理解了。

另外,本人不屑於與這個操着半通不通鳥語的痞夫在中文論壇上交流。如果他需要提高英文水平,建議他好好去上個學。

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