新一代华裔科学家在生命科学中的贡献：一个初步的客观分析
郑言
吴瑞先生曾对华裔科学家的对生命科学的贡献多有论述。这篇文章中的资料和分析可视作对他的论述的一个具体的补充。
每个科学家都希望自己的工作得到科学同仁的承认，他们往往在他们的科学报告中，论述自己工作的重要性。但最重要的客观标准是他们的工作是否得到同行的认可。科学家的实际贡献是可以用他的研究工作产生的影响（Impact）来衡量。科学论文的引用率 (Citation Index) 应该是衡量科学家影响一个客观的标准。
我对十五位新一代知名的华裔科学家的代表性论文的引用率作了一个初步调查。所选择的论文不包括综述文章，仅仅是首发的研究论文 (RESEARCH PAPERS). 我相信我已尽了自己的最大努力，检查了这些科学家的全部重要研究论文。下面给出的仅仅是他们的最重要的论文的引用率。如有遗漏，请诸位同仁补充。这些论文仅仅包括这些科学家在他们自己的实验室发表的文章，不包括他们独立以前在他们的导师的实验室里发表的论文。
这些资料来源于2004年6月1日进行的ISI Search. 具体请见下列（http://isi10.newisiknowledge.com/）
关于这些资料的一些说明。
１． 王晓东和袁钧瑛的关于细胞凋亡的工作是第一流的，他们的论文产生了巨大的影响。特别是王晓东，他的四篇论文，引用率都在一千次以上。
２． 引用率在三百次以上的，一般说来是历程碑Milestone 论文。共有四位华裔学者达此标准：他们是王晓凡，傅新元，鲁白，和钱卓。他们的这些论文往往开创了一个新的研究领域。例如钱卓的关于聪敏老鼠的论文，是生物史上第一次人工改变智力。这篇论文被引用了312次。傅新元1992年的Cell 论文，第一次阐明STAT 信号通路的分子机理。鲁白的1996 Nature 论文被引用310次。这篇论文首次指明神经细胞因子对记忆的影响。王晓凡的1995年的PNAS论文，被引用超过四百次。 在这篇论文中，王第一次报道细胞周期抑制因子p21可以被p53以外的TGF-beta所调控。
３． 引用率超过两百次的论文大都是极为重要的经典的发现。例如邓初夏关于BRCA1的发现，傅向东发现的调节mRNA 剪切的新型蛋白激酶。邓兴旺发现的COP 基因。管坤良关于Mek 蛋白激酶的研究，和施一公关于Smad蛋白结构的研究。
４． 引用率超过一百次的论文都是很优秀论文。例如饶毅关于Slit 基因在神经发育中的重要作用的一系列论文，许田关于TSC 基因的研究，施一公在结构生物学中的许多论文，和韩岷的关于RAS-RAF信号通路的研究。这些论文有的发表的时间还短，相信他们在今后几年中的引用率会逐步上升。
５． 骆利群是近年来在神经领域出人头地的一匹黑马，作了极出色的工作。他的重要论文发表的时间还短，相信他工作的影响会越来越大。
６． 引用率的高低也受此领域的大小的影响。细胞凋亡领域是近年来影响最大的一个领域。Medline 检索细胞凋亡Apoptosis 可找到超过八万四千篇论文。这领域内有影响力的论文的引用率必然会相对的高。韩岷研究的线虫的Ras-Raf 通路，领域较小，虽然他做了极优秀的工作，论文的引用率相对偏低是可以理解的。
７． 发表在三大杂志：Cell, Nature, Science 上的论文一般引用率较高。但不是绝对的。不少三大杂志的论文并没有被广泛引用。关键是论文的质量。例如王晓凡的数篇论文引用率很高，但都不是这三大杂志的论文。
８． 值得注意的是，十五位中暂时领先的四位科学家，王晓东， 袁钧瑛， 王晓凡和傅新元都是早期CUSBEA 项目的成员。傅向东，韩岷，管坤良，及黑马骆利群也是其成员。
９． 虽然这些华裔学者已取得了引人注目的成就，但大多数人并没有成为各领域中的当然的领袖或顶级权威。除了王晓东和袁俊瑛，大多数新一代华裔科学家仍有一段艰苦的路要走，才能成为各领域中的泰斗。
具体论文引用数据：
王晓东 德州西南大学 引用率超过三百次的论文：六篇。 其中有四篇论文分别被引用了超过一千次
Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
Liu XS, Kim CN, Yang J, Jemmerson R, Wang XD CELL 86 (1): 147-157 JUL 12 1996 Times Cited: 1936
Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
Yang J, Liu XS, Bhalla K, Kim CN, Ibrado AM, Cai JY, Peng TI, Jones DP, Wang XD SCIENCE 275 (5303): 1129-1132 FEB 21 1997 Times Cited: 2177
DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis Liu XS, Zou H, Slaughter C, Wang XD CELL 89 (2): 175-184 APR 18 1997 Times Cited: 915
Apaf-1, a human protein homologous to C-elegans CED-4, participates in cytochrome c-dependent activation of caspase-3 Zou H, Henzel WJ, Liu XS, Lutschg A, Wang XD CELL 90 (3): 405-413 AUG 8 1997 Times Cited: 1452
The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis Liu XS, Li P, Widlak P, Zou H, Luo X, Garrard WT, Wang XD
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 95 (15): 8461-8466 JUL 21 1998 Times Cited: 223
Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors Luo X, Budihardjo I, Zou H, Slaughter C, Wang XD
CELL 94 (4): 481-490 AUG 21 1998 Times Cited: 1128
Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition Du CY, Fang M, Li YC, Li L, Wang XD. CELL 102 (1): 33-42 JUL 7 2000 Times Cited: 735
Endonuclease G is an apoptotic DNase when released from mitochondria Li LY, Luo L, Wang XD
NATURE 412 (6842): 95-99 JUL 5 2001 Times Cited: 272
袁钧瑛 哈佛大学 引用率超过三百次的论文：四篇。其中有一篇论文被引用了超过一千次
PREVENTION OF VERTEBRATE NEURONAL DEATH BY THE CRMA GENE
GAGLIARDINI V, FERNANDEZ PA, LEE RKK, DREXLER HCA, ROTELLO RJ, FISHMAN MC, YUAN J
SCIENCE 263 (5148): 826-828 FEB 11 1994 Times Cited: 566
ICH-1, AN ICE/CED-3-RELATED GENE, ENCODES BOTH POSITIVE AND NEGATIVE REGULATORS OF PROGRAMMED CELL-DEATH WANG L, MIURA M, BERGERON L, ZHU H, YUAN JY
CELL 78 (5): 739-750 SEP 9 1994 Times Cited: 675
Inhibition of ICE slows ALS in mice Friedlander RM, Brown RH, Gagliardini V, Wang J, Yuan JY
NATURE 388 (6637): 31-31 JUL 3 1997 Times Cited: 172
Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE
Wang SY, Miura M, Jung YK, Zhu H, Li E, Yuan JY CELL 92 (4): 501-509 FEB 20 1998 Times Cited: 198
Defects in regulation of apoptosis in caspase-2-deficient mice Bergeron L, Perez GI, Macdonald G, Shi LF, Sun Y, Jurisicova A, Varmuza S, Latham KE, Flaws JA, Salter JCM, Hara H, Moskowitz MA, Li E, Greenberg A, Tilly JL, Yuan JY GENES & DEVELOPMENT 12 (9): 1304-1314 MAY 1 1998 Times Cited: 237
Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
Li HL, Zhu H, Xu CJ, Yuan JY CELL 94 (4): 491-501 AUG 21 1998 Times Cited: 1263
Caspase-8 is required for cell death induced by expanded polyglutamine repeats Sanchez I, Xu CJ, Juo P, Kakizaka A, Blenis J, Yuan JY NEURON 22 (3): 623-633 MAR 1999 Times Cited: 185
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta
Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yankner BA, Yuan JY NATURE 403 (6765): 98-103 JAN 6 2000
Times Cited: 351
Cross-talk between two cysteine protease families: Activation of caspase-12 by calpain in apoptosis
Nakagawa T, Yuan JY JOURNAL OF CELL BIOLOGY 150 (4): 887-894 AUG 21 2000 Times Cited: 191
王晓凡 杜克大学 引用率超过三百次的论文：一篇。 另有一篇JBC论文分别被引用了超过两百次
A TRANSFORMING GROWTH-FACTOR-BETA TYPE-I RECEPTOR THAT SIGNALS TO ACTIVATE GENE-EXPRESSION BASSING CH, YINGLING JM, HOWE DJ, WANG TW, HE WW, GUSTAFSON ML, SHAH P, DONAHOE PK, WANG XF SCIENCE 263 (5143): 87-89 JAN 7 1994 Times Cited: 251
TRANSFORMING GROWTH-FACTOR-BETA INDUCES THE CYCLIN-DEPENDENT KINASE INHIBITOR P21 THROUGH A P53-INDEPENDENT MECHANISM DATTO MB, LI Y, PANUS JF, HOWE DJ, XIONG Y, WANG XF PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 92 (12): 5545-5549 JUN 6 1995 Times Cited: 465
FUNCTIONAL-ANALYSIS OF THE TRANSFORMING GROWTH-FACTOR-BETA RESPONSIVE ELEMENTS IN THE WAF1/CIP1/P21 PROMOTER DATTO MB, YU Y, WANG XF
JOURNAL OF BIOLOGICAL CHEMISTRY 270 (48): 28623-28628 DEC 1 1995 Times Cited: 253
Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth Yingling JM, Das P, Savage C, Zhang M, Padgett RW, Wang XF, PNAS 93 (17): 8940-8944 AUG 20 1996 Times Cited: 113
Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding protein Yingling JM, Datto MB, Wong C, Frederick JP, Liberati NT, Wang XF, MCB 17 (12): 7019-7028 DEC 1997 Times Cited: 190
TGF-beta-induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB-binding protein Shen X, Hu PP, Liberati NT, Datto MB, Frederick JP, Wang XF MCB 9 (12): 3309-3319 DEC 1998
Times Cited: 100
Smad3-Smad4 and AP-1 complexes synergize in tranxxxxional activation of the c-Jun promoter by transforming growth factor beta Wong C, Rougier-Chapman EM, Frederick JP, Datto MB, Liberati NT, Li JM, Wang XF MBC 19 (3): 1821-1830 MAR 1999 Times Cited: 116
Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction Datto MB, Frederick JP, Pan LH, Borton AJ, Zhuang Y, Wang XF
MOLECULAR AND CELLULAR BIOLOGY 19 (4): 2495-2504 APR 1999 Times Cited: 125
Smads bind directly to the Jun family of AP-1 tranxxxxion factors
Liberati NT, Datto MB, Frederick JP, Shen X, Wong C, Rougier-Chapman EM, Wang XF
PNAS 96 (9): 4844-4849 APR 27 1999 Times Cited: 145
ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses
Bao SD, Tibbetts RS, Brumbaugh KM, Fang YN, Richardson DA, Ali A, Chen SM, Abraham RT, Wang XF
NATURE 411 (6840): 969-974 JUN 21 2001 Times Cited: 62
傅新元 耶鲁大学 引用率超过三百次的论文：两篇
A TRANxxxxION FACTOR WITH SH2 AND SH3 DOMAINS IS DIRECTLY ACTIVATED BY AN INTERFERON-ALPHA-INDUCED CYTOPLASMIC PROTEIN TYROSINE KINASE(S)
FU XY CELL 70 (2): 323-335 JUL 24 1992 Times Cited: 340
TRANxxxxION FACTOR P91 INTERACTS WITH THE EPIDERMAL GROWTH-FACTOR RECEPTOR AND MEDIATES ACTIVATION OF THE C-FOS GENE PROMOTER
FU XY, ZHANG JJ CELL 74 (6): 1135-1145 SEP 24 1993 Times Cited: 275
Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21(WAF1/CIP1) mediated by STAT1
Chin YE, Kitagawa M, Su WCS, You ZH, Iwamoto Y, Fu XY SCIENCE 272 (5262): 719-722 MAY 3 1996
Times Cited: 406
Activation of Stat1 by mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism
Su WCS, Kitagawa M, Xue NR, Xie B, Garofalo S, Cho J, Deng CX, Horton WA, Fu XY NATURE 386 (6622): 288-292 MAR 20 1997 Times Cited: 138
Activation of the STAT signaling pathway can cause expression of caspase 1 and apoptosis
Chin YE, Kitagawa M, Kuida K, Flavell RA, Fu XY MCB 17 (9): 5328-5337 SEP 1997 Times Cited: 221
STAT5 interaction with the T cell receptor complex and stimulation of T cell proliferation
Welte T, Leitenberg D, Dittel BN, al-Ramadi BK, Xie B, Chin YE, Janeway CA, Bothwell ALM, Bottomly K, Fu XY
SCIENCE 283 (5399): 222-225 JAN 8 1999 Times Cited: 57
鲁白 美国国立卫生院 引用率超过三百次的论文：一篇
NEUROTROPHIN-3 POTENTIATES NEURONAL-ACTIVITY AND INHIBITS GAMMA-AMINOBUTYRATERGIC SYNAPTIC TRANSMISSION IN CORTICAL-NEURONS
KIM HG, WANG T, OLAFSSON P, LU B PNAS 91 (25): 12341-12345 DEC 6 1994
Times Cited: 130
NITRIC-OXIDE MEDIATES ACTIVITY-DEPENDENT SYNAPTIC SUPPRESSION AT DEVELOPING NEUROMUSCULAR SYNAPSES WANG T, XIE ZP, LU B NATURE 374 (6519): 262-266 MAR 16 1995
Times Cited: 140
NEUROTROPHINS PROMOTE MATURATION OF DEVELOPING NEUROMUSCULAR SYNAPSES
WANG T, XIE KW, LU B JOURNAL OF NEUROSCIENCE 15 (7): 4796-4805 Part 1 JUL 1995
Times Cited: 110
Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus
Figurov A, PozzoMiller LD, Olafsson P, Wang T, Lu B
NATURE 381 (6584): 706-709 JUN 20 1996 Times Cited: 310
Impairments in high-frequency transmission, synaptic vesicle docking, and synaptic protein distribution in the hippocampus of BDNF knockout mice Pozzo-Miller LD, Gottschalk W, Zhang L, McDermott K, Du J, Gopalakrishnan R, Oho C, Sheng ZH, Lu B JOURNAL OF NEUROSCIENCE 19 (12): 4972-4983 JUN 15 1999
Times Cited: 103
PI-3 kinase and IP3 are both necessary and sufficient to mediate NT3-induced synaptic potentiation
Yang F, He XP, Feng LY, Mizuno K, Liu XW, Russell J, Xiong WC, Lu B
NATURE NEUROSCIENCE 4 (1): 19-28 JAN 2001 Times Cited: 47
钱卓 普林斯顿大学 引用率超过三百次的论文：一篇
Genetic enhancement of learning and memory in mice Tang YP, Shimizu E, Dube GR, Rampon C, Kerchner GA, Zhuo M, Liu GS, Tsien JZ NATURE 401 (6748): 63-69 SEP 2 1999 Times Cited: 312
Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice Rampon C, Tang YP, Goodhouse J, Shimizu E, Kyin M, Tsien JZ NATURE NEUROSCIENCE 3 (3): 238-244 MAR 2000 Times Cited: 89
NMDA receptor-dependent synaptic reinforcement as a crucial process for memory consolidation
Shimizu E, Tang YP, Rampon C, Tsien JZ SCIENCE 290 (5494): 1170-1174 NOV 10 2000 Times Cited: 68
Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces
Feng RB, Rampon C, Tang YP, Shrom D, Jin J, Kim M, Sopher B, Martin GM, Kim SH, Langdon RB, Sisodia SS, Tsien JZ NEURON 32 (5): 911-926 DEC 6 2001 Times Cited: 44
邓初夏 美国国立卫生院NIH 引用率超过两百次的论文：两篇
Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction Xu XL, Weinstein M, Li CL, Naski M, Cohen RI, Ornitz DM, Leder P, Deng CX
DEVELOPMENT 125 (4): 753-765 FEB 1998 Times Cited: 158
The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice
Yang X, Li CL, Xu XL, Deng CX. PNAS 95 (7): 3667-3672 MAR 31 1998 Times Cited: 99
Centrosome amplification and a defective G(2)-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells Xu XL, Weaver Z, Linke SP, Li CL, Gotay J, Wang XW, Harris CC, Ried T, Deng CX
MOLECULAR CELL 3 (3): 389-395 MAR 1999 Times Cited: 271
A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability Shen SX, Weaver Z, Xu XL, Li CL, Weinstein M, Chen L, Guan XY, Ried T, Deng CX
ONCOGENE 17 (24): 3115-3124 DEC 17 1998 Times Cited: 103
Angiogenesis defects and mesenchymal apoptosis in mice lacking SMAD5 Yang X, Castilla LH, Xu XL, Li CL, Gotay J, Weinstein M, Liu PP, Deng CX DEVELOPMENT 126 (8): 1571-1580 APR 1999 Times Cited: 116
Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation Xu XL, Wagner KU, Larson D, Weaver Z, Li CL, Ried T, Hennighausen L, Wynshaw-Boris A, Deng CX
NATURE GENETICS 22 (1): 37-43 MAY 1999 Times Cited: 206
Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis
Xu XL, Qiao WH, Linke SP, Cao L, Li WM, Furth PA, Harris CC, Deng CX NATURE GENETICS 28 (3): 266-271 JUL 2001 Times Cited: 53
傅向东 加州大学 SAN DIEGO 引用率超过两百次的论文：两篇
SPECIFIC COMMITMENT OF DIFFERENT PREMESSENGER RNAS TO SPLICING BY SINGLE SR PROTEINS FU XD NATURE 365 (6441): 82-85 SEP 2 1993 Times Cited: 203
A SERINE KINASE REGULATES INTRACELLULAR-LOCALIZATION OF SPLICING FACTORS IN THE CELL CYCLE GUI JF, LANE WS, FU XD NATURE 369 (6482): 678-682 JUN 23 1994 Times Cited: 240
A complex of nuclear proteins mediates SR protein binding to a purine-rich splicing enhancer
Yeakley JM, Morfin JP, Rosenfeld MG, Fu XD
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 93 (15): 7582-7587 JUL 23 1996 Times Cited: 57
RNA splicing specificity determined by the coordinated action of RNA recognition motifs in SR proteins
Chandler SD, Mayeda A, Yeakley JM, Krainer AR, Fu XD PNAS 94 (8): 3596-3601 APR 15 1997 Times Cited: 55
A protein related to splicing factor U2AF(35) that interacts with U2AF(65) and SR proteins in splicing of pre-mRNA Tronchere H, Wang JW, Fu XD NATURE 388 (6640): 397-400 JUL 24 1997 Times Cited: 36
SRPK2: A differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells Wang HY, Lin W, Dyck JA, Yeakley JM, Zhou SY, Cantley LC, Fu XD JCB 140 (4): 737-750 FEB 23 1998 Times Cited: 98
邓兴旺 耶鲁大学 引用率超过两百次的论文：一篇
COP1, AN ARABIDOPSIS REGULATORY GENE, ENCODES A PROTEIN WITH BOTH A ZINC-BINDING MOTIF AND A G-BETA HOMOLOGOUS DOMAIN. DENG XW, MATSUI M, WEI N, WAGNER D, CHU AM, FELDMANN KA, QUAIL PH CELL 71 (5): 791-801 NOV 27 1992 Times Cited: 254
ARABIDOPSIS COP9 IS A COMPONENT OF A NOVEL SIGNALING COMPLEX MEDIATING LIGHT CONTROL OF DEVELOPMENT WEI N, CHAMOVITZ DA, DENG XW CELL 78 (1): 117-124 JUL 15 1994
Times Cited: 132
LIGHT INACTIVATION OF ARABIDOPSIS PHOTOMORPHOGENIC REPRESSOR COP1 INVOLVES A CELL-SPECIFIC REGULATION OF ITS NUCLEOCYTOPLASMIC PARTITIONING VONARNIM AG, DENG XW CELL 79 (6): 1035-1045 DEC 16 1994 Times Cited: 155
THE NOVEL COMPONENTS OF THE ARABIDOPSIS LIGHT SIGNALING PATHWAY MAY DEFINE A GROUP OF GENERAL DEVELOPMENTAL REGULATORS SHARED BY BOTH ANIMAL AND PLANT KINGDOMS CHAMOVITZ DA, DENG XW CELL 82 (3): 353-354 AUG 11 1995 Times Cited: 36
The COP9 complex, a novel multisubunit nuclear regulator involved in light control of a plant developmental switch Chamovitz DA, Wei N, Osterlund MT, vonArnim AG, Staub JM, Matsui M, Deng XW
CELL 86 (1): 115-121 JUL 12 1996 Times Cited: 111
Targeted destabilization of HY5 during light-regulated development of Arabidopsis Osterlund MT, Hardtke CS, Wei N, Deng XW NATURE 405 (6785): 462-466 MAY 25 2000 Times Cited: 163
Direct interaction of Arabidopsis cryptochromes with COP1 in light control development Wang HY, Ma LG, Li JM, Zhao HY, Deng XW. SCIENCE 294 (5540): 154-158 OCT 5 2001 Times Cited: 50
Interactions of the COP9 signalosome with the E3 ubiquitin ligase SCFTIR1 in mediating auxin response
Schwechheimer C, Serino G, Callis J, Crosby WL, Lyapina S, Deshaies RJ, Gray WM, Estelle M, Deng XW
SCIENCE 292 (5520): 1379-1382 MAY 18 2001 Times Cited: 133
管坤良 密执安大学 引用率超过两百次的论文：一篇
ACTIVATION OF MEK FAMILY KINASES REQUIRES PHOSPHORYLATION OF 2 CONSERVED SER/THR RESIDUES ZHENG CF, GUAN KL EMBO J. 13 (5): 1123-1131 MAR 1 1994 Times Cited: 223
MEK-2, A CAENORHABDITIS-ELEGANS MAP KINASE KINASE, FUNCTIONS IN RAS-MEDIATED VULVAR INDUCTION AND OTHER DEVELOPMENTAL EVENTS WU Y, HAN M, GUAN KL
GENES & DEVELOPMENT 9 (6): 742-755 MAR 15 1995 Times Cited: 41
Differential regulation of FUS3 MAP kinase by tyrosine-specific phosphatases PTP2/PTP3 and dual-specificity phosphatase MSG5 in Saccharomyces cerevisiae Zhan XL, Deschenes RJ, Guan KL. G&D 11 (13): 1690-1702 JUL 1 1997 Times Cited: 55
The kinase suppressor of Ras (KSR) modulates growth factor and Ras signaling by uncoupling Elk-1 phosphorylation from MAP kinase activation Sugimoto T, Stewart S, Han M, Guan KL
EMBO JOURNAL 17 (6): 1717-1727 MAR 16 1998 Times Cited: 52
A specific protein-protein interaction accounts for the in vivo substrate selectivity of Ptp3 towards the Fus3 MAP kinase Zhan XL, Guan KL. G&D 13 (21): 2811-2827 NOV 1 1999 Times Cited: 20
Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601
Zhang BH, Guan KL EMBO JOURNAL 19 (20): 5429-5439 OCT 16 2000 Times Cited: 25
Regulation of STAT3 by direct binding to the Rac1 GTPase Simon AR, Vikis HG, Stewart S, Fanburg BL, Cochran BH, Guan KL SCIENCE 290 (5489): 144-147 OCT 6 2000 Times Cited: 39
The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf
Li WQ, Han M, Guan KL GENES & DEVELOPMENT 14 (8): 895-900 APR 15 2000 Times Cited: 24
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
Inoki K, Li Y, Zhu TQ, Wu J, Guan KL NATURE CELL BIOLOGY 4 (9): 648-657 SEP 2002 Times Cited: 107
Positive and negative regulation of Raf kinase activity and function by phosphorylation
Chong H, Lee J, Guan KL EMBO JOURNAL 20 (14): 3716-3727 JUL 16 2001 Times Cited: 30
施一公 普林斯顿大学 引用率超过两百次的论文：一篇
Crystal structure of a Smad MH1 domain bound to DNA: Insights on DNA binding in TGF-beta signaling
Shi YG, Wang YF, Jayaraman L, Yang HJ, Massague J, Pavletich NP CELL 94 (5): 585-594 SEP 4 1998
Times Cited: 227
Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1 Qin HX, Srinivasula SM, Wu G, Fernandes-Alnemri T, Alnemri ES, Shi YG NATURE 399 (6736): 549-557 JUN 10 1999 Times Cited: 113
Structural basis of Smad2 recognition by the Smad anchor for receptor activation
Wu G, Chen YG, Ozdamar B, Gyuricza CA, Chong PA, Wrana JL, Massague J, Shi YG
SCIENCE 287 (5450): 92-97 JAN 7 2000 Times Cited: 66
Structural and biochemical basis of apoptotic activation by Smac/DIABLO Chai JJ, Du CY, Wu JW, Kyin S, Wang XD, Shi YG NATURE 406 (6798): 855-862 AUG 24 2000 Times Cited: 191
Structural basis of IAP recognition by Smac/DIABLO Wu G, Chai JJ, Suber TL, Wu JW, Du CY, Wang XD, Shi YG NATURE 408 (6815): 1008-1012 DEC 21 2000 Times Cited: 135
Structural basis of caspase-7 inhibition by XIAP Chai JJ, Shiozaki E, Srinivasula SM, Wu Q, Dataa P, Alnemri ES, Shi YG CELL 104 (5): 769-780 MAR 9 2001 Times Cited: 110
Crystal structure of a procaspase-7 zymogen: Mechanisms of activation and substrate binding Chai JJ, Wu Q, Shiozaki E, Srinivasula SM, Alnemri ES, Shi YG CELL 107 (3): 399-407 NOV 2 2001 Times Cited: 37
Structural mechanism of Smad4 recognition by the nuclear oncoprotein ski: Insights on Ski-mediated repression of TGF-beta signaling Wu JW, Krawitz AR, Chai JJ, Li WY, Zhang FJ, Luo KX, Shi YG CELL 111 (3): 357-367 NOV 1 2002 Times Cited: 21
Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde
Hu M, Li PW, Li MY, Li WY, Yao TT, Wu JW, Gu W, Cohen RE, Shi YG CELL 111 (7): 1041-1054 DEC 27 2002 Times Cited: 31
Mechanism of XIAP-mediated inhibition of caspase-9 Shiozaki EN, Chai JJ, Rigotti DJ, Riedl SJ, Li PW, Srinivasula SM, Alnemri ES, Fairman R, Shi YG MOLECULAR CELL 11 (2): 519-527 FEB 2003 Times Cited: 24
饶毅 华盛顿大学 引用率超过一百次的论文：四篇
A single morphogenetic field gives rise to two retina primordia under the influence of the prechordal plate
Li HS, Tierney C, Wen L, Wu JY, Rao Y DEVELOPMENT 124 (3): 603-615 FEB 1997 Times Cited: 104
Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons Li HS, Chen JH, Wu W, Fagaly T, Zhou LJ, Yuan WL, Dupuis S, Jiang ZH, Nash W, Gick C, Ornitz DM, Wu JY, Rao Y CELL 96 (6): 807-818 MAR 19 1999 Times Cited: 146
Directional guidance of neuronal migration in the olfactory system by the protein Slit Wu W, Wong K, Chen JH, Jiang ZH, Dupuls S, Wu JY, Rao Y NATURE 400 (6742): 331-336 JUL 22 1999 Times Cited: 162
Cellular and molecular guidance of GABAergic neuronal migration from an extracortical origin to the neocortex Zhu Y, Li HS, Zhou LJ, Wu JY, Rao Y NEURON 23 (3): 473-485 JUL 1999 Times Cited: 107
Signal transduction in neuronal migration: Roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway Wong K, Ren XR, Huang YZ, Xie Y, Liu GF, Saito H, Tang H, Wen L, Brady-Kalnay SM, Mei L, Wu JY, Xiong WC, Rao Y CELL 107 (2): 209-221 OCT 19 2001 Times Cited: 70
许田 耶鲁大学 引用率超过一百次的论文：两篇。 其中一篇是与其原导师Rubin 合作的论文。
IDENTIFYING TUMOR SUPPRESSORS IN GENETIC MOSAICS - THE DROSOPHILA LATS GENE ENCODES A PUTATIVE PROTEIN-KINASE XU T, WANG WY, ZHANG S, STEWART RA, YU W
DEVELOPMENT 121 (4): 1053-1063 APR 1995 Times Cited: 85
KUZ, a conserved metalloprotease-disintegrin protein with two roles in Drosophila neurogenesis
Rooke J, Pan D, Xu T, Rubin GM SCIENCE 273 (5279): 1227-1231 AUG 30 1996 Times Cited: 166
slimb coordinates wg and dpp expression in the dorsal-ventral and anterior-posterior axes during limb development Theodosiou NA, Zhang S, Wang WY, Xu T DEVELOPMENT 125 (17): 3411-3416 SEP 1998 Times Cited: 37
Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction
St John MAR, Tao WF, Fei XL, Fukumoto R, Carcangiu ML, Brownstein DG, Parlow AF, McGrath J, Xu TA
NATURE GENETICS 21 (2): 182-186 FEB 1999 Times Cited: 47
Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity
Tao WF, Zhang S, Turenchalk GS, Stewart RA, St John MAR, Chen WL, Xu T NATURE GENETICS 21 (2): 177-181 FEB 1999 Times Cited: 56
Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size Potter CJ, Huang H, Xu T CELL 105 (3): 357-368 MAY 4 2001 Times Cited: 123
Drosophila atrophin homolog functions as a tranxxxxional corepressor in multiple developmental processes
Zhang S, Xu L, Lee J, Xu T CELL 108 (1): 45-56 JAN 11 2002 Times Cited: 21
Akt regulates growth by directly phosphorylating Tsc2 Potter CJ, Pedraza LG, Xu T
NATURE CELL BIOLOGY 4 (9): 658-665 SEP 2002 Times Cited: 71
韩岷 科罗拉多大学 引用率超过一百次的论文：一篇
SUPPRESSION OF ACTIVATED LET-60 RAS PROTEIN DEFINES A ROLE OF CAENORHABDITIS-ELEGANS SUR-1 MAP KINASE IN VULVAR DIFFERENTIATION
WU Y, HAN M GENES & DEVELOPMENT 8 (2): 147-159 JAN 1994 Times Cited: 91
SUR-2, A NOVEL GENE, FUNCTIONS LATE IN THE LET-60 RAS-MEDIATED SIGNALING PATHWAY DURING CAENORHABDITIS-ELEGANS VULVAR INDUCTION SINGH N, HAN M GENES & DEVELOPMENT 9 (18): 2251-2265 SEP 15 1995 Times Cited: 42
THE C-ELEGANS KSR-1 GENE ENCODES A NOVEL RAF-RELATED KINASE INVOLVED IN RAS-MEDIATED SIGNAL-TRANSDUCTION SUNDARAM M, HAN M CELL 83 (6): 889-901 DEC 15 1995
Times Cited: 115
SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C-elegans Sieburth DS, Sun Q, Han M CELL 94 (1): 119-130 JUL 10 1998 Times Cited: 50
A PP2A regulatory subunit positively regulates Ras-mediated signaling during Caenorhabditis elegans vulval induction Sieburth DS, Sundaram M, Howard RM, Han M. GENES & DEVELOPMENT 13 (19): 2562-2569 OCT 1 1999 Times Cited: 28
骆利群 斯坦福大学 引用率超过一百次的论文：一篇
Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis
Lee T, Luo LQ NEURON 22 (3): 451-461 MAR 1999 Times Cited: 152
Essential roles of Drosophila RhoA in the regulation of neuroblast proliferation and dendritic but not axonal morphogenesis Lee TM, Winter C, Marticke SS, Lee A, Luo LQ NEURON 25 (2): 307-316 FEB 2000
Times Cited: 64
Cell-autonomous requirement of the USP/EcR-B ecdysone receptor for mushroom body neuronal remodeling in Drosophila Lee T, Marticke S, Sung C, Robinow S, Luo LQ NEURON 28 (3): 807-818 DEC 2000 Times Cited: 24
Regulating axon branch stability: The role of p190 RhoGAP in repressing a retraction signaling pathway
Billuart P, Winter CG, Maresh A, Zhao XS, Luo LQ CELL 107 (2): 195-207 OCT 19 2001. Times Cited: 49 Drosophila Rho-associated kinase (Drok) links frizzled-mediated planar cell polarity signaling to the actin cytoskeleton Winter CG, Wang B, Ballew A, Royou A, Karess R, Axelrod JD, Luo LQ CELL 105 (1): 81-91 APR 6 2001 Times Cited: 81
Target neuron prespecification in the olfactory map of Drosophila Jefferis GSXE, Marin EC, Stocker RF, Luo LQ
NATURE 414 (6860): 204-208 NOV 8 2001 Times Cited: 31
Rac GTPases control axon growth, guidance and branching Ng J, Nardine T, Harms M, Tzu J, Goldstein A, Sun Y, Dietzl G, Dickson BJ, Luo LQ NATURE 416 (6879): 442-447 MAR 28 2002 Times Cited: 54
Representation of the glomerular olfactory map in the Drosophila brain Marin EC, Jefferis GSXE, Komiyama T, Zhu HT, Luo LQ CELL 109 (2): 243-255 APR 19 2002 Times Cited: 33
