新一代華裔科學家在生命科學中的貢獻：一個初步的客觀分析
鄭言
吳瑞先生曾對華裔科學家的對生命科學的貢獻多有論述。這篇文章中的資料和分析可視作對他的論述的一個具體的補充。
每個科學家都希望自己的工作得到科學同仁的承認，他們往往在他們的科學報告中，論述自己工作的重要性。但最重要的客觀標準是他們的工作是否得到同行的認可。科學家的實際貢獻是可以用他的研究工作產生的影響（Impact）來衡量。科學論文的引用率 (Citation Index) 應該是衡量科學家影響一個客觀的標準。
我對十五位新一代知名的華裔科學家的代表性論文的引用率作了一個初步調查。所選擇的論文不包括綜述文章，僅僅是首發的研究論文 (RESEARCH PAPERS). 我相信我已盡了自己的最大努力，檢查了這些科學家的全部重要研究論文。下面給出的僅僅是他們的最重要的論文的引用率。如有遺漏，請諸位同仁補充。這些論文僅僅包括這些科學家在他們自己的實驗室發表的文章，不包括他們獨立以前在他們的導師的實驗室里發表的論文。
這些資料來源於2004年6月1日進行的ISI Search. 具體請見下列（http://isi10.newisiknowledge.com/）
關於這些資料的一些說明。
１． 王曉東和袁鈞瑛的關於細胞凋亡的工作是第一流的，他們的論文產生了巨大的影響。特別是王曉東，他的四篇論文，引用率都在一千次以上。
２． 引用率在三百次以上的，一般說來是歷程碑Milestone 論文。共有四位華裔學者達此標準：他們是王曉凡，傅新元，魯白，和錢卓。他們的這些論文往往開創了一個新的研究領域。例如錢卓的關於聰敏老鼠的論文，是生物史上第一次人工改變智力。這篇論文被引用了312次。傅新元1992年的Cell 論文，第一次闡明STAT 信號通路的分子機理。魯白的1996 Nature 論文被引用310次。這篇論文首次指明神經細胞因子對記憶的影響。王曉凡的1995年的PNAS論文，被引用超過四百次。 在這篇論文中，王第一次報道細胞周期抑制因子p21可以被p53以外的TGF-beta所調控。
３． 引用率超過兩百次的論文大都是極為重要的經典的發現。例如鄧初夏關於BRCA1的發現，傅向東發現的調節mRNA 剪切的新型蛋白激酶。鄧興旺發現的COP 基因。管坤良關於Mek 蛋白激酶的研究，和施一公關於Smad蛋白結構的研究。
４． 引用率超過一百次的論文都是很優秀論文。例如饒毅關於Slit 基因在神經發育中的重要作用的一系列論文，許田關於TSC 基因的研究，施一公在結構生物學中的許多論文，和韓岷的關於RAS-RAF信號通路的研究。這些論文有的發表的時間還短，相信他們在今後幾年中的引用率會逐步上升。
５． 駱利群是近年來在神經領域出人頭地的一匹黑馬，作了極出色的工作。他的重要論文發表的時間還短，相信他工作的影響會越來越大。
６． 引用率的高低也受此領域的大小的影響。細胞凋亡領域是近年來影響最大的一個領域。Medline 檢索細胞凋亡Apoptosis 可找到超過八萬四千篇論文。這領域內有影響力的論文的引用率必然會相對的高。韓岷研究的線蟲的Ras-Raf 通路，領域較小，雖然他做了極優秀的工作，論文的引用率相對偏低是可以理解的。
７． 發表在三大雜誌：Cell, Nature, Science 上的論文一般引用率較高。但不是絕對的。不少三大雜誌的論文並沒有被廣泛引用。關鍵是論文的質量。例如王曉凡的數篇論文引用率很高，但都不是這三大雜誌的論文。
８． 值得注意的是，十五位中暫時領先的四位科學家，王曉東， 袁鈞瑛， 王曉凡和傅新元都是早期CUSBEA 項目的成員。傅向東，韓岷，管坤良，及黑馬駱利群也是其成員。
９． 雖然這些華裔學者已取得了引人注目的成就，但大多數人並沒有成為各領域中的當然的領袖或頂級權威。除了王曉東和袁俊瑛，大多數新一代華裔科學家仍有一段艱苦的路要走，才能成為各領域中的泰斗。
具體論文引用數據：
王曉東 德州西南大學 引用率超過三百次的論文：六篇。 其中有四篇論文分別被引用了超過一千次
Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
Liu XS, Kim CN, Yang J, Jemmerson R, Wang XD CELL 86 (1): 147-157 JUL 12 1996 Times Cited: 1936
Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
Yang J, Liu XS, Bhalla K, Kim CN, Ibrado AM, Cai JY, Peng TI, Jones DP, Wang XD SCIENCE 275 (5303): 1129-1132 FEB 21 1997 Times Cited: 2177
DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis Liu XS, Zou H, Slaughter C, Wang XD CELL 89 (2): 175-184 APR 18 1997 Times Cited: 915
Apaf-1, a human protein homologous to C-elegans CED-4, participates in cytochrome c-dependent activation of caspase-3 Zou H, Henzel WJ, Liu XS, Lutschg A, Wang XD CELL 90 (3): 405-413 AUG 8 1997 Times Cited: 1452
The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis Liu XS, Li P, Widlak P, Zou H, Luo X, Garrard WT, Wang XD
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 95 (15): 8461-8466 JUL 21 1998 Times Cited: 223
Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors Luo X, Budihardjo I, Zou H, Slaughter C, Wang XD
CELL 94 (4): 481-490 AUG 21 1998 Times Cited: 1128
Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition Du CY, Fang M, Li YC, Li L, Wang XD. CELL 102 (1): 33-42 JUL 7 2000 Times Cited: 735
Endonuclease G is an apoptotic DNase when released from mitochondria Li LY, Luo L, Wang XD
NATURE 412 (6842): 95-99 JUL 5 2001 Times Cited: 272
袁鈞瑛 哈佛大學 引用率超過三百次的論文：四篇。其中有一篇論文被引用了超過一千次
PREVENTION OF VERTEBRATE NEURONAL DEATH BY THE CRMA GENE
GAGLIARDINI V, FERNANDEZ PA, LEE RKK, DREXLER HCA, ROTELLO RJ, FISHMAN MC, YUAN J
SCIENCE 263 (5148): 826-828 FEB 11 1994 Times Cited: 566
ICH-1, AN ICE/CED-3-RELATED GENE, ENCODES BOTH POSITIVE AND NEGATIVE REGULATORS OF PROGRAMMED CELL-DEATH WANG L, MIURA M, BERGERON L, ZHU H, YUAN JY
CELL 78 (5): 739-750 SEP 9 1994 Times Cited: 675
Inhibition of ICE slows ALS in mice Friedlander RM, Brown RH, Gagliardini V, Wang J, Yuan JY
NATURE 388 (6637): 31-31 JUL 3 1997 Times Cited: 172
Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE
Wang SY, Miura M, Jung YK, Zhu H, Li E, Yuan JY CELL 92 (4): 501-509 FEB 20 1998 Times Cited: 198
Defects in regulation of apoptosis in caspase-2-deficient mice Bergeron L, Perez GI, Macdonald G, Shi LF, Sun Y, Jurisicova A, Varmuza S, Latham KE, Flaws JA, Salter JCM, Hara H, Moskowitz MA, Li E, Greenberg A, Tilly JL, Yuan JY GENES & DEVELOPMENT 12 (9): 1304-1314 MAY 1 1998 Times Cited: 237
Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
Li HL, Zhu H, Xu CJ, Yuan JY CELL 94 (4): 491-501 AUG 21 1998 Times Cited: 1263
Caspase-8 is required for cell death induced by expanded polyglutamine repeats Sanchez I, Xu CJ, Juo P, Kakizaka A, Blenis J, Yuan JY NEURON 22 (3): 623-633 MAR 1999 Times Cited: 185
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta
Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yankner BA, Yuan JY NATURE 403 (6765): 98-103 JAN 6 2000
Times Cited: 351
Cross-talk between two cysteine protease families: Activation of caspase-12 by calpain in apoptosis
Nakagawa T, Yuan JY JOURNAL OF CELL BIOLOGY 150 (4): 887-894 AUG 21 2000 Times Cited: 191
王曉凡 杜克大學 引用率超過三百次的論文：一篇。 另有一篇JBC論文分別被引用了超過兩百次
A TRANSFORMING GROWTH-FACTOR-BETA TYPE-I RECEPTOR THAT SIGNALS TO ACTIVATE GENE-EXPRESSION BASSING CH, YINGLING JM, HOWE DJ, WANG TW, HE WW, GUSTAFSON ML, SHAH P, DONAHOE PK, WANG XF SCIENCE 263 (5143): 87-89 JAN 7 1994 Times Cited: 251
TRANSFORMING GROWTH-FACTOR-BETA INDUCES THE CYCLIN-DEPENDENT KINASE INHIBITOR P21 THROUGH A P53-INDEPENDENT MECHANISM DATTO MB, LI Y, PANUS JF, HOWE DJ, XIONG Y, WANG XF PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 92 (12): 5545-5549 JUN 6 1995 Times Cited: 465
FUNCTIONAL-ANALYSIS OF THE TRANSFORMING GROWTH-FACTOR-BETA RESPONSIVE ELEMENTS IN THE WAF1/CIP1/P21 PROMOTER DATTO MB, YU Y, WANG XF
JOURNAL OF BIOLOGICAL CHEMISTRY 270 (48): 28623-28628 DEC 1 1995 Times Cited: 253
Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth Yingling JM, Das P, Savage C, Zhang M, Padgett RW, Wang XF, PNAS 93 (17): 8940-8944 AUG 20 1996 Times Cited: 113
Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding protein Yingling JM, Datto MB, Wong C, Frederick JP, Liberati NT, Wang XF, MCB 17 (12): 7019-7028 DEC 1997 Times Cited: 190
TGF-beta-induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB-binding protein Shen X, Hu PP, Liberati NT, Datto MB, Frederick JP, Wang XF MCB 9 (12): 3309-3319 DEC 1998
Times Cited: 100
Smad3-Smad4 and AP-1 complexes synergize in tranxxxxional activation of the c-Jun promoter by transforming growth factor beta Wong C, Rougier-Chapman EM, Frederick JP, Datto MB, Liberati NT, Li JM, Wang XF MBC 19 (3): 1821-1830 MAR 1999 Times Cited: 116
Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction Datto MB, Frederick JP, Pan LH, Borton AJ, Zhuang Y, Wang XF
MOLECULAR AND CELLULAR BIOLOGY 19 (4): 2495-2504 APR 1999 Times Cited: 125
Smads bind directly to the Jun family of AP-1 tranxxxxion factors
Liberati NT, Datto MB, Frederick JP, Shen X, Wong C, Rougier-Chapman EM, Wang XF
PNAS 96 (9): 4844-4849 APR 27 1999 Times Cited: 145
ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses
Bao SD, Tibbetts RS, Brumbaugh KM, Fang YN, Richardson DA, Ali A, Chen SM, Abraham RT, Wang XF
NATURE 411 (6840): 969-974 JUN 21 2001 Times Cited: 62
傅新元 耶魯大學 引用率超過三百次的論文：兩篇
A TRANxxxxION FACTOR WITH SH2 AND SH3 DOMAINS IS DIRECTLY ACTIVATED BY AN INTERFERON-ALPHA-INDUCED CYTOPLASMIC PROTEIN TYROSINE KINASE(S)
FU XY CELL 70 (2): 323-335 JUL 24 1992 Times Cited: 340
TRANxxxxION FACTOR P91 INTERACTS WITH THE EPIDERMAL GROWTH-FACTOR RECEPTOR AND MEDIATES ACTIVATION OF THE C-FOS GENE PROMOTER
FU XY, ZHANG JJ CELL 74 (6): 1135-1145 SEP 24 1993 Times Cited: 275
Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21(WAF1/CIP1) mediated by STAT1
Chin YE, Kitagawa M, Su WCS, You ZH, Iwamoto Y, Fu XY SCIENCE 272 (5262): 719-722 MAY 3 1996
Times Cited: 406
Activation of Stat1 by mutant fibroblast growth-factor receptor in thanatophoric dysplasia type II dwarfism
Su WCS, Kitagawa M, Xue NR, Xie B, Garofalo S, Cho J, Deng CX, Horton WA, Fu XY NATURE 386 (6622): 288-292 MAR 20 1997 Times Cited: 138
Activation of the STAT signaling pathway can cause expression of caspase 1 and apoptosis
Chin YE, Kitagawa M, Kuida K, Flavell RA, Fu XY MCB 17 (9): 5328-5337 SEP 1997 Times Cited: 221
STAT5 interaction with the T cell receptor complex and stimulation of T cell proliferation
Welte T, Leitenberg D, Dittel BN, al-Ramadi BK, Xie B, Chin YE, Janeway CA, Bothwell ALM, Bottomly K, Fu XY
SCIENCE 283 (5399): 222-225 JAN 8 1999 Times Cited: 57
魯白 美國國立衛生院 引用率超過三百次的論文：一篇
NEUROTROPHIN-3 POTENTIATES NEURONAL-ACTIVITY AND INHIBITS GAMMA-AMINOBUTYRATERGIC SYNAPTIC TRANSMISSION IN CORTICAL-NEURONS
KIM HG, WANG T, OLAFSSON P, LU B PNAS 91 (25): 12341-12345 DEC 6 1994
Times Cited: 130
NITRIC-OXIDE MEDIATES ACTIVITY-DEPENDENT SYNAPTIC SUPPRESSION AT DEVELOPING NEUROMUSCULAR SYNAPSES WANG T, XIE ZP, LU B NATURE 374 (6519): 262-266 MAR 16 1995
Times Cited: 140
NEUROTROPHINS PROMOTE MATURATION OF DEVELOPING NEUROMUSCULAR SYNAPSES
WANG T, XIE KW, LU B JOURNAL OF NEUROSCIENCE 15 (7): 4796-4805 Part 1 JUL 1995
Times Cited: 110
Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus
Figurov A, PozzoMiller LD, Olafsson P, Wang T, Lu B
NATURE 381 (6584): 706-709 JUN 20 1996 Times Cited: 310
Impairments in high-frequency transmission, synaptic vesicle docking, and synaptic protein distribution in the hippocampus of BDNF knockout mice Pozzo-Miller LD, Gottschalk W, Zhang L, McDermott K, Du J, Gopalakrishnan R, Oho C, Sheng ZH, Lu B JOURNAL OF NEUROSCIENCE 19 (12): 4972-4983 JUN 15 1999
Times Cited: 103
PI-3 kinase and IP3 are both necessary and sufficient to mediate NT3-induced synaptic potentiation
Yang F, He XP, Feng LY, Mizuno K, Liu XW, Russell J, Xiong WC, Lu B
NATURE NEUROSCIENCE 4 (1): 19-28 JAN 2001 Times Cited: 47
錢卓 普林斯頓大學 引用率超過三百次的論文：一篇
Genetic enhancement of learning and memory in mice Tang YP, Shimizu E, Dube GR, Rampon C, Kerchner GA, Zhuo M, Liu GS, Tsien JZ NATURE 401 (6748): 63-69 SEP 2 1999 Times Cited: 312
Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice Rampon C, Tang YP, Goodhouse J, Shimizu E, Kyin M, Tsien JZ NATURE NEUROSCIENCE 3 (3): 238-244 MAR 2000 Times Cited: 89
NMDA receptor-dependent synaptic reinforcement as a crucial process for memory consolidation
Shimizu E, Tang YP, Rampon C, Tsien JZ SCIENCE 290 (5494): 1170-1174 NOV 10 2000 Times Cited: 68
Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces
Feng RB, Rampon C, Tang YP, Shrom D, Jin J, Kim M, Sopher B, Martin GM, Kim SH, Langdon RB, Sisodia SS, Tsien JZ NEURON 32 (5): 911-926 DEC 6 2001 Times Cited: 44
鄧初夏 美國國立衛生院NIH 引用率超過兩百次的論文：兩篇
Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction Xu XL, Weinstein M, Li CL, Naski M, Cohen RI, Ornitz DM, Leder P, Deng CX
DEVELOPMENT 125 (4): 753-765 FEB 1998 Times Cited: 158
The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice
Yang X, Li CL, Xu XL, Deng CX. PNAS 95 (7): 3667-3672 MAR 31 1998 Times Cited: 99
Centrosome amplification and a defective G(2)-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells Xu XL, Weaver Z, Linke SP, Li CL, Gotay J, Wang XW, Harris CC, Ried T, Deng CX
MOLECULAR CELL 3 (3): 389-395 MAR 1999 Times Cited: 271
A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability Shen SX, Weaver Z, Xu XL, Li CL, Weinstein M, Chen L, Guan XY, Ried T, Deng CX
ONCOGENE 17 (24): 3115-3124 DEC 17 1998 Times Cited: 103
Angiogenesis defects and mesenchymal apoptosis in mice lacking SMAD5 Yang X, Castilla LH, Xu XL, Li CL, Gotay J, Weinstein M, Liu PP, Deng CX DEVELOPMENT 126 (8): 1571-1580 APR 1999 Times Cited: 116
Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation Xu XL, Wagner KU, Larson D, Weaver Z, Li CL, Ried T, Hennighausen L, Wynshaw-Boris A, Deng CX
NATURE GENETICS 22 (1): 37-43 MAY 1999 Times Cited: 206
Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis
Xu XL, Qiao WH, Linke SP, Cao L, Li WM, Furth PA, Harris CC, Deng CX NATURE GENETICS 28 (3): 266-271 JUL 2001 Times Cited: 53
傅向東 加州大學 SAN DIEGO 引用率超過兩百次的論文：兩篇
SPECIFIC COMMITMENT OF DIFFERENT PREMESSENGER RNAS TO SPLICING BY SINGLE SR PROTEINS FU XD NATURE 365 (6441): 82-85 SEP 2 1993 Times Cited: 203
A SERINE KINASE REGULATES INTRACELLULAR-LOCALIZATION OF SPLICING FACTORS IN THE CELL CYCLE GUI JF, LANE WS, FU XD NATURE 369 (6482): 678-682 JUN 23 1994 Times Cited: 240
A complex of nuclear proteins mediates SR protein binding to a purine-rich splicing enhancer
Yeakley JM, Morfin JP, Rosenfeld MG, Fu XD
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 93 (15): 7582-7587 JUL 23 1996 Times Cited: 57
RNA splicing specificity determined by the coordinated action of RNA recognition motifs in SR proteins
Chandler SD, Mayeda A, Yeakley JM, Krainer AR, Fu XD PNAS 94 (8): 3596-3601 APR 15 1997 Times Cited: 55
A protein related to splicing factor U2AF(35) that interacts with U2AF(65) and SR proteins in splicing of pre-mRNA Tronchere H, Wang JW, Fu XD NATURE 388 (6640): 397-400 JUL 24 1997 Times Cited: 36
SRPK2: A differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells Wang HY, Lin W, Dyck JA, Yeakley JM, Zhou SY, Cantley LC, Fu XD JCB 140 (4): 737-750 FEB 23 1998 Times Cited: 98
鄧興旺 耶魯大學 引用率超過兩百次的論文：一篇
COP1, AN ARABIDOPSIS REGULATORY GENE, ENCODES A PROTEIN WITH BOTH A ZINC-BINDING MOTIF AND A G-BETA HOMOLOGOUS DOMAIN. DENG XW, MATSUI M, WEI N, WAGNER D, CHU AM, FELDMANN KA, QUAIL PH CELL 71 (5): 791-801 NOV 27 1992 Times Cited: 254
ARABIDOPSIS COP9 IS A COMPONENT OF A NOVEL SIGNALING COMPLEX MEDIATING LIGHT CONTROL OF DEVELOPMENT WEI N, CHAMOVITZ DA, DENG XW CELL 78 (1): 117-124 JUL 15 1994
Times Cited: 132
LIGHT INACTIVATION OF ARABIDOPSIS PHOTOMORPHOGENIC REPRESSOR COP1 INVOLVES A CELL-SPECIFIC REGULATION OF ITS NUCLEOCYTOPLASMIC PARTITIONING VONARNIM AG, DENG XW CELL 79 (6): 1035-1045 DEC 16 1994 Times Cited: 155
THE NOVEL COMPONENTS OF THE ARABIDOPSIS LIGHT SIGNALING PATHWAY MAY DEFINE A GROUP OF GENERAL DEVELOPMENTAL REGULATORS SHARED BY BOTH ANIMAL AND PLANT KINGDOMS CHAMOVITZ DA, DENG XW CELL 82 (3): 353-354 AUG 11 1995 Times Cited: 36
The COP9 complex, a novel multisubunit nuclear regulator involved in light control of a plant developmental switch Chamovitz DA, Wei N, Osterlund MT, vonArnim AG, Staub JM, Matsui M, Deng XW
CELL 86 (1): 115-121 JUL 12 1996 Times Cited: 111
Targeted destabilization of HY5 during light-regulated development of Arabidopsis Osterlund MT, Hardtke CS, Wei N, Deng XW NATURE 405 (6785): 462-466 MAY 25 2000 Times Cited: 163
Direct interaction of Arabidopsis cryptochromes with COP1 in light control development Wang HY, Ma LG, Li JM, Zhao HY, Deng XW. SCIENCE 294 (5540): 154-158 OCT 5 2001 Times Cited: 50
Interactions of the COP9 signalosome with the E3 ubiquitin ligase SCFTIR1 in mediating auxin response
Schwechheimer C, Serino G, Callis J, Crosby WL, Lyapina S, Deshaies RJ, Gray WM, Estelle M, Deng XW
SCIENCE 292 (5520): 1379-1382 MAY 18 2001 Times Cited: 133
管坤良 密執安大學 引用率超過兩百次的論文：一篇
ACTIVATION OF MEK FAMILY KINASES REQUIRES PHOSPHORYLATION OF 2 CONSERVED SER/THR RESIDUES ZHENG CF, GUAN KL EMBO J. 13 (5): 1123-1131 MAR 1 1994 Times Cited: 223
MEK-2, A CAENORHABDITIS-ELEGANS MAP KINASE KINASE, FUNCTIONS IN RAS-MEDIATED VULVAR INDUCTION AND OTHER DEVELOPMENTAL EVENTS WU Y, HAN M, GUAN KL
GENES & DEVELOPMENT 9 (6): 742-755 MAR 15 1995 Times Cited: 41
Differential regulation of FUS3 MAP kinase by tyrosine-specific phosphatases PTP2/PTP3 and dual-specificity phosphatase MSG5 in Saccharomyces cerevisiae Zhan XL, Deschenes RJ, Guan KL. G&D 11 (13): 1690-1702 JUL 1 1997 Times Cited: 55
The kinase suppressor of Ras (KSR) modulates growth factor and Ras signaling by uncoupling Elk-1 phosphorylation from MAP kinase activation Sugimoto T, Stewart S, Han M, Guan KL
EMBO JOURNAL 17 (6): 1717-1727 MAR 16 1998 Times Cited: 52
A specific protein-protein interaction accounts for the in vivo substrate selectivity of Ptp3 towards the Fus3 MAP kinase Zhan XL, Guan KL. G&D 13 (21): 2811-2827 NOV 1 1999 Times Cited: 20
Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601
Zhang BH, Guan KL EMBO JOURNAL 19 (20): 5429-5439 OCT 16 2000 Times Cited: 25
Regulation of STAT3 by direct binding to the Rac1 GTPase Simon AR, Vikis HG, Stewart S, Fanburg BL, Cochran BH, Guan KL SCIENCE 290 (5489): 144-147 OCT 6 2000 Times Cited: 39
The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf
Li WQ, Han M, Guan KL GENES & DEVELOPMENT 14 (8): 895-900 APR 15 2000 Times Cited: 24
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
Inoki K, Li Y, Zhu TQ, Wu J, Guan KL NATURE CELL BIOLOGY 4 (9): 648-657 SEP 2002 Times Cited: 107
Positive and negative regulation of Raf kinase activity and function by phosphorylation
Chong H, Lee J, Guan KL EMBO JOURNAL 20 (14): 3716-3727 JUL 16 2001 Times Cited: 30
施一公 普林斯頓大學 引用率超過兩百次的論文：一篇
Crystal structure of a Smad MH1 domain bound to DNA: Insights on DNA binding in TGF-beta signaling
Shi YG, Wang YF, Jayaraman L, Yang HJ, Massague J, Pavletich NP CELL 94 (5): 585-594 SEP 4 1998
Times Cited: 227
Structural basis of procaspase-9 recruitment by the apoptotic protease-activating factor 1 Qin HX, Srinivasula SM, Wu G, Fernandes-Alnemri T, Alnemri ES, Shi YG NATURE 399 (6736): 549-557 JUN 10 1999 Times Cited: 113
Structural basis of Smad2 recognition by the Smad anchor for receptor activation
Wu G, Chen YG, Ozdamar B, Gyuricza CA, Chong PA, Wrana JL, Massague J, Shi YG
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Structural and biochemical basis of apoptotic activation by Smac/DIABLO Chai JJ, Du CY, Wu JW, Kyin S, Wang XD, Shi YG NATURE 406 (6798): 855-862 AUG 24 2000 Times Cited: 191
Structural basis of IAP recognition by Smac/DIABLO Wu G, Chai JJ, Suber TL, Wu JW, Du CY, Wang XD, Shi YG NATURE 408 (6815): 1008-1012 DEC 21 2000 Times Cited: 135
Structural basis of caspase-7 inhibition by XIAP Chai JJ, Shiozaki E, Srinivasula SM, Wu Q, Dataa P, Alnemri ES, Shi YG CELL 104 (5): 769-780 MAR 9 2001 Times Cited: 110
Crystal structure of a procaspase-7 zymogen: Mechanisms of activation and substrate binding Chai JJ, Wu Q, Shiozaki E, Srinivasula SM, Alnemri ES, Shi YG CELL 107 (3): 399-407 NOV 2 2001 Times Cited: 37
Structural mechanism of Smad4 recognition by the nuclear oncoprotein ski: Insights on Ski-mediated repression of TGF-beta signaling Wu JW, Krawitz AR, Chai JJ, Li WY, Zhang FJ, Luo KX, Shi YG CELL 111 (3): 357-367 NOV 1 2002 Times Cited: 21
Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde
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Mechanism of XIAP-mediated inhibition of caspase-9 Shiozaki EN, Chai JJ, Rigotti DJ, Riedl SJ, Li PW, Srinivasula SM, Alnemri ES, Fairman R, Shi YG MOLECULAR CELL 11 (2): 519-527 FEB 2003 Times Cited: 24
饒毅 華盛頓大學 引用率超過一百次的論文：四篇
A single morphogenetic field gives rise to two retina primordia under the influence of the prechordal plate
Li HS, Tierney C, Wen L, Wu JY, Rao Y DEVELOPMENT 124 (3): 603-615 FEB 1997 Times Cited: 104
Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons Li HS, Chen JH, Wu W, Fagaly T, Zhou LJ, Yuan WL, Dupuis S, Jiang ZH, Nash W, Gick C, Ornitz DM, Wu JY, Rao Y CELL 96 (6): 807-818 MAR 19 1999 Times Cited: 146
Directional guidance of neuronal migration in the olfactory system by the protein Slit Wu W, Wong K, Chen JH, Jiang ZH, Dupuls S, Wu JY, Rao Y NATURE 400 (6742): 331-336 JUL 22 1999 Times Cited: 162
Cellular and molecular guidance of GABAergic neuronal migration from an extracortical origin to the neocortex Zhu Y, Li HS, Zhou LJ, Wu JY, Rao Y NEURON 23 (3): 473-485 JUL 1999 Times Cited: 107
Signal transduction in neuronal migration: Roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway Wong K, Ren XR, Huang YZ, Xie Y, Liu GF, Saito H, Tang H, Wen L, Brady-Kalnay SM, Mei L, Wu JY, Xiong WC, Rao Y CELL 107 (2): 209-221 OCT 19 2001 Times Cited: 70
許田 耶魯大學 引用率超過一百次的論文：兩篇。 其中一篇是與其原導師Rubin 合作的論文。
IDENTIFYING TUMOR SUPPRESSORS IN GENETIC MOSAICS - THE DROSOPHILA LATS GENE ENCODES A PUTATIVE PROTEIN-KINASE XU T, WANG WY, ZHANG S, STEWART RA, YU W
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KUZ, a conserved metalloprotease-disintegrin protein with two roles in Drosophila neurogenesis
Rooke J, Pan D, Xu T, Rubin GM SCIENCE 273 (5279): 1227-1231 AUG 30 1996 Times Cited: 166
slimb coordinates wg and dpp expression in the dorsal-ventral and anterior-posterior axes during limb development Theodosiou NA, Zhang S, Wang WY, Xu T DEVELOPMENT 125 (17): 3411-3416 SEP 1998 Times Cited: 37
Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction
St John MAR, Tao WF, Fei XL, Fukumoto R, Carcangiu ML, Brownstein DG, Parlow AF, McGrath J, Xu TA
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Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity
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Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size Potter CJ, Huang H, Xu T CELL 105 (3): 357-368 MAY 4 2001 Times Cited: 123
Drosophila atrophin homolog functions as a tranxxxxional corepressor in multiple developmental processes
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Akt regulates growth by directly phosphorylating Tsc2 Potter CJ, Pedraza LG, Xu T
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韓岷 科羅拉多大學 引用率超過一百次的論文：一篇
SUPPRESSION OF ACTIVATED LET-60 RAS PROTEIN DEFINES A ROLE OF CAENORHABDITIS-ELEGANS SUR-1 MAP KINASE IN VULVAR DIFFERENTIATION
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SUR-2, A NOVEL GENE, FUNCTIONS LATE IN THE LET-60 RAS-MEDIATED SIGNALING PATHWAY DURING CAENORHABDITIS-ELEGANS VULVAR INDUCTION SINGH N, HAN M GENES & DEVELOPMENT 9 (18): 2251-2265 SEP 15 1995 Times Cited: 42
THE C-ELEGANS KSR-1 GENE ENCODES A NOVEL RAF-RELATED KINASE INVOLVED IN RAS-MEDIATED SIGNAL-TRANSDUCTION SUNDARAM M, HAN M CELL 83 (6): 889-901 DEC 15 1995
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SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C-elegans Sieburth DS, Sun Q, Han M CELL 94 (1): 119-130 JUL 10 1998 Times Cited: 50
A PP2A regulatory subunit positively regulates Ras-mediated signaling during Caenorhabditis elegans vulval induction Sieburth DS, Sundaram M, Howard RM, Han M. GENES & DEVELOPMENT 13 (19): 2562-2569 OCT 1 1999 Times Cited: 28
駱利群 斯坦福大學 引用率超過一百次的論文：一篇
Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis
Lee T, Luo LQ NEURON 22 (3): 451-461 MAR 1999 Times Cited: 152
Essential roles of Drosophila RhoA in the regulation of neuroblast proliferation and dendritic but not axonal morphogenesis Lee TM, Winter C, Marticke SS, Lee A, Luo LQ NEURON 25 (2): 307-316 FEB 2000
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Cell-autonomous requirement of the USP/EcR-B ecdysone receptor for mushroom body neuronal remodeling in Drosophila Lee T, Marticke S, Sung C, Robinow S, Luo LQ NEURON 28 (3): 807-818 DEC 2000 Times Cited: 24
Regulating axon branch stability: The role of p190 RhoGAP in repressing a retraction signaling pathway
Billuart P, Winter CG, Maresh A, Zhao XS, Luo LQ CELL 107 (2): 195-207 OCT 19 2001. Times Cited: 49 Drosophila Rho-associated kinase (Drok) links frizzled-mediated planar cell polarity signaling to the actin cytoskeleton Winter CG, Wang B, Ballew A, Royou A, Karess R, Axelrod JD, Luo LQ CELL 105 (1): 81-91 APR 6 2001 Times Cited: 81
Target neuron prespecification in the olfactory map of Drosophila Jefferis GSXE, Marin EC, Stocker RF, Luo LQ
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Rac GTPases control axon growth, guidance and branching Ng J, Nardine T, Harms M, Tzu J, Goldstein A, Sun Y, Dietzl G, Dickson BJ, Luo LQ NATURE 416 (6879): 442-447 MAR 28 2002 Times Cited: 54
Representation of the glomerular olfactory map in the Drosophila brain Marin EC, Jefferis GSXE, Komiyama T, Zhu HT, Luo LQ CELL 109 (2): 243-255 APR 19 2002 Times Cited: 33
