1.中國醫學科學院、協和醫科大學校長劉德培 中國科學院院士院士， 中國醫學科學院基礎所生化博士， 加州大學舊金山分校博士後 代表文章: (1). U MJ, Lv X, Hao DL, Zhao GW, Wu XS, Wu F, Liu DP, Liang CC. MafK/NF-E2 p18 is required for beta-globin genes activation by mediating the proximity of LCR and active beta-globin genes in MEL cell line.Int J Biochem Cell Biol . 2008;40(8):1481-93. (2). Zhou GL, Xin L, Song W, Di LJ, Liu G, Wu XS, Liu DP, Liang CC. Active chromatin hub of the mouse alpha-globin locus forms in a transcription factory of clustered housekeeping genes. Mol Cell Biol. 2006 Jul;26(13):5096-105. (3). Li HL, Wang AB, Zhang R, Wei YS, Chen HZ, She ZG, Huang Y, Liu DP, Liang CC. A20 inhibits oxidized low-density lipoprotein-induced apoptosis through negative Fas/Fas ligand-dependent activation of caspase-8 and mitochondrial pathways in murine RAW264.7 macrophages. J Cell Physiol. 2006 Aug;208(2):307-18. (4). Liu DP.[Research of whole genome regulatory network in postgenomic era] Zhonghua Yi Xue Za Zhi (中華醫學雜誌）. 2005 Sep 21;85(36):2526. (5). Shen W, Huang Y, Tang Y, Liu DP, Liang CC. A general method to modify BACs to generate large recombinant DNA fragments.Mol Biotechnol. 2005 Nov;31 (3):181-6. (6). Lv X, Shi HZ, Liu DP, Hao DL, Zhang S, Xin L, Li XG, Xu HM, Liang CC. High fidelity screening of regulatory sequences in apolipoprotein(a)- plasminogen cluster. Int J Biochem Cell Biol. 2005 Sep;37(9):1846-57. (7). Wu XS, Xin L, Yin WX, Shang XY, Lu L, Watt RM, Cheah KS, Huang JD, Liu DP, Liang CC. Increased efficiency of oligonucleotide-mediated gene repair through slowing replication fork progression.Proc Natl Acad Sci U S A. 2005 Feb 15;102(7): 2508-13 (8). Liu DP, Schmidt C, Billings T, Davisson MT. Quantitative PCR genotyping assay for the Ts65Dn mouse model of Down syndrome.Biotechniques. 2003 Dec; 35(6):1170-4。 (9). Feng DX, Liu DP, Huang Y, Wu L, Li TC, Wu M, Tang XB, Liang CC.The expression of human alpha -like globin genes in transgenic mice mediated by bacterial artificial chromosome.Proc Natl Acad Sci U S A. 2001 Dec 18;98(26) :15073-7 2. 北京大學生命科學院院長饒毅 加州大學舊金山分校神經生物學博士 哈佛大學博士後 美國西北大學神經科學研究所副所長，正教授 北京生命科學研究所副所長 代表文章: (1). Li X, Gao X, Liu G, Xiong W, Wu J, Rao Y. Netrin signal transduction and the guanine nucleotide exchange factor DOCK180 in attractive signaling. Nat Neurosci. 2008 Jan;11(1):28-35 (2). Cafferty P, Yu L, Long H, Rao Y. Semaphorin-1a functions as a guidance receptor in the Drosophila visual system.J Neurosci. 2006 Apr 12;26(15):3999 -4003. (3). Jiang H, Rao Y. Axon formation: fate versus growth.Nat Neurosci. 2005 May;8(5):544-6. (4). Jiang H, Guo W, Liang X, Rao Y. Both the establishment and the maintenance of neuronal polarity require active mechanisms: critical roles of GSK-3beta and its upstream regulators.Cell. 2005 Jan 14;120(1):123-35 (5). Ward ME, Wu JY, Rao Y. Visualization of spatially and temporally regulated N-WASP activity during cytoskeletal reorganization in living cells .Proc Natl Acad Sci U S A. 2004 Jan 27;101(4):970-4 (6). Ruan W, Long H, Vuong DH, Rao Y. Bifocal is a downstream target of the Ste20-like serine/threonine kinase misshapen in regulating photoreceptor growth cone targeting in Drosophila.Neuron. 2002 Dec 5;36(5):831-42. (7). Wong K, Ren XR, Huang YZ, Xie Y, Liu G, Saito H, Tang H, Wen L, Brady- Kalnay SM, Mei L, Wu JY, Xiong WC, Rao Y. Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway.Cell. 2001 (8). Wu W, Wong K, Chen J, Jiang Z, Dupuis S, Wu JY, Rao Y. Directional guidance of neuronal migration in the olfactory system by the protein Slit. Nature. 1999 Jul 22;400(6742):331-6. 3. 北京生命科學研究所王曉東所長 美國科學院院士 美國休斯醫學研究所研究員 美國德州大學西南醫學中心教授 代表文章: (1). Lin Li, Ranny Mathew Thomas, Hidetaka Suzuki, Jef K. De Brabander, Xiaodong Wang, Patrick G. Harran, "A Small Molecule Smac Mimic Potentiates TRAIL- and TNF-Mediated Cell Death" Science, 305(5689):1471-1474, September 2004; (2). Xuejun Jiang, Hyun-Eui Kim, Hongjun Shu, Yingmin Zhao, Haichao Zhang, James Kofron, Jennifer Donnelly, Dave Burns, Shi-chung Ng, Saul Rosenberg, and Xiaodong Wang, "Distinctive roles of PHAP proteins and prothymosin- alpha in a death Regulatory Pathway." Science, 299:214-5, January 2003; (3). Chunying Du, Min Fang, Yucheng Li, Lily Li, and Xiaodong Wang, "Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition." Cell, 102:33-42, 2000; (4). Xuesong Liu, Caryn Naekyung Kim, Jie Yang, Ronald Jemmerson, and Xiaodong Wang, "Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c." Cell, 86:147-157, 1996; (5). Xu Luo, Imawati Budihardjo, Hua Zou, Clive Slaughter, and Xiaodong Wang , "Bid, a Bcl-2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors." Cell, 94:481-490, 1998; (6). Lai Wang, Fenghe Du, and Xiaodong Wang, "TNF-_ induces two distinct caspase-8 activation pathways" Cell, 133:693-703, May 2008. 4. 北京大學基礎醫學院院長新任院長尹玉新 中國協和醫科大學醫學博士 美國北卡大學教堂山分校遺傳與分子生物學博士 美國索克（Salk)研究所博士後 哥倫比亞大學放射腫瘤學副教授 代表文章: (1). Shen WH, Balajee AS, Wang J, Wu H, Eng C, Pandolfi PP and Yin Y. Essential role for nuclear PTEN in maintaining chromosomal integrity. Cell 128:157-70, 2007. (2). Wang J, Yin DP, Liu YX, Baer R and Yin Y. Dual specificity phosphatase 1/ CL100 is a direct transcriptional target of E2F-1 in the apoptotic response to oxidative stress. Cancer Res 67:6737-44, 2007. (3). Wang J, Liu YX, Hande MP, Wong AC, Jin YJ and Yin Y. TAp73 is a downstream target of p53 in controlling the cellular defense against stress. 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Yin Y, Tainsky MA, Bischoff FZ, Strong LC and Wahl GM. Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles. Cell 70:937-48, 1992. 5. 復旦大學生命科學學院長馬紅 麻省理工學院生物學博士 加州理工學院博士後 賓西法尼亞州立大學生物系傑出教授 代表文章: (1).Quan, L.*, Xiao, R.*, Li, W., Oh, S.-A., Ambrose, J.C., Cyr, R., Twell, D., Ma, H. 2008. Functionally divergence of the duplicated Arabidopsis AtKIN14a and AtKIN14b genes: critical roles in meiosis and gametophyte development. Plant J. 53: 1013-1026. (Equal contribution) (2).Hu, W., Ma, H. 2006. Characterization of a novel putative zinc-finger gene MIF1: involvement in multiple hormonal regulation of Arabidopsis development. Plant J. 45: 399-422. (cover) (3). Zhang, W.*, Sun, Y.*, Timofejeva, L., Chen, C., Grossniklaus, U., Ma, H . 2006. Control of Arabidopsis tapetum development by DYSFUNCTIONAL TAPETUM 1 (DYT1) encoding a putative bHLH transcription factor. (* Equal contribution) Development , 133: 3085-3095. (4). Li, W., Chen, C., Markmann-Mulisch, U., Timofejeva, L., Schmelzer, E., Ma, H .*, and Reiss, B.* 2004. The Arabidopsis RAD51 gene is dispensable for vegetative growth but required for meiosis . Proc. Natl. Acad. Sci. USA. 101 : 10596-10601. (* Corresponding authors); (5). Yang, X.-H., Makaroff, C.*, Ma, H .* 2003. The Arabidopsis MALE MEIOCYTE DEATH1 gene encodes a PHD-finger protein that is required for male meiosis. Plant Cell 15 : 1281-1295. (6). Zhao, D.-Z., Wang, G.-F., Speal, B., Ma, H . 2002. The EXCESS MICROSPOROCYTES1 gene encodes a putative leucine-rich repeat receptor protein kinase that controls somatic and reproductive cell fates in the Arabidopsis anther. Genes & Dev . 16 : 2021-2031. (7). Ma, H ., dePamphilis, C. 2000. The ABCs of floral evolution. Cell 101 : 5-8. (8). Ma, H. 1997. The on and off of floral regulatory genes. Cell 89: 821- 824. (9). Mizukami, Y., Ma, H. 1992. Ectopic expression of the floral homeotic gene AGAMOUS in transgenic Arabidopsis plants alters floral organ identity. Cell 71: 119-131. (10). Ma, H., Yanofsky, M.F., Meyerowitz, E.M. 1991. AGL1-AGL6, An Arabidopsis gene family with similarity to floral homeotic and transcription factor genes. Genes & Dev. 5: 484-495. 6. 中國科學院上海生命科學院院長裴剛 中國科學院院士、第三世界科學院院士 美國北卡大學教堂山分校生化博士 杜克大學醫學院博士後 (1).Shi Y, Feng Y, Kang J, Liu C, Li Z, Li D, Cao W, Qiu J, Guo Z, Bi E, Zang L, Lu C, Zhang JZ, Pei G. Critical regulation of CD4+ T cell survival and autoimmunity by beta-arrestin 1.Nat Immunol. 2007 Aug;8(8):817-24. (2).Ni Y, Zhao X, Bao G, Zou L, Teng L, Wang Z, Song M, Xiong J, Bai Y, Pei G. Activation of beta2-adrenergic receptor stimulates gamma-secretase activity and accelerates amyloid plaque formation.Nat Med. 2006 Dec;12(12): 1390-6. (3). Wang Y, Tang Y, Teng L, Wu Y, Zhao X, Pei G. Association of beta- arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling.Nat Immunol. 2006 Feb;7(2):139-47 (4). Kang J, Shi Y, Xiang B, Qu B, Su W, Zhu M, Zhang M, Bao G, Wang F, Zhang X, Yang R, Fan F, Chen X, Pei G, Ma L. A nuclear function of beta- arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription.Cell. 2005 Dec 2;123(5):833-47. (5). Luan B, Zhang Z, Wu Y, Kang J, Pei G. Beta-arrestin2 functions as a phosphorylation-regulated suppressor of UV-induced NF-kappaB activation.EMBO J. 2005 Dec 21;24(24):4237-46. (6). Gao H, Sun Y, Wu Y, Luan B, Wang Y, Qu B, Pei G. Identification of beta -arrestin2 as a G protein-coupled receptor-stimulated regulator of NF-kappaB pathways. Mol Cell. 2004 May 7;14(3):303-17. (7). Wang P, Gao H, Ni Y, Wang B, Wu Y, Ji L, Qin L, Ma L, Pei G. Beta- arrestin 2 functions as a G-protein-coupled receptor-activated regulator of oncoprotein Mdm2.J Biol Chem. 2003 Feb 21;278(8):6363-70. 7. 中國科學院廣州生物醫藥與健康研究院院長陳凌 美國印第安那大學生化與分子生物博士 哈佛大學醫學院Dana-Farber癌症研究所博士後 美國Lexicon Genetics Inc, 生物製藥部主任 (1).Casimiro DR, Chen L, Fu TM, Evans RK, Caulfield MJ, Davies ME, Tang A, Chen M, Huang L, Harris V, Freed DC, Wilson KA, Dubey S, Zhu DM, Nawrocki D, Mach H, Troutman R, Isopi L, Williams D, Hurni W, Xu Z, Smith JG, Wang S, Liu X, Guan L, Long R, Trigona W, Heidecker GJ, Perry HC, Persaud N, Toner TJ, Su Q, Liang X, Youil R, Chastain M, Bett AJ, Volkin DB, Emini EA, Shiver JW. Comparative immunogenicity in rhesus monkeys of DNA plasmid, recombinant poxvirus and replication-defective adenoviral vectors expressing a human immunodeficiency virus type 1 gag gene.J Virology.2003, 77:6305- 6313. (2). Shiver JW, Fu TM, Chen L, Casimiro DR, Davies ME, Evans RK, Zhang ZQ, Simon AJ, Trigona WL, Dubey SA, Huang L, Harris VA, Long RS, Liang X, Handt L, Schleif WA, Zhu L, Freed DC, Persaud NV, Guan L, Punt KS, Tang A, Chen M, Wilson KA, Collins KB, Heidecker GJ, Fernandez VR, Perry HC, Joyce JG, Grimm KM, Cook JC, Keller PM, Kresock DS, Mach H, Troutman RD, Isopi LA, Williams DM, Xu Z, Bohannon KE, Volkin DB, Montefiori DC, Miura A, Krivulka GR, Lifton MA, Kuroda MJ, Schmitz JE, Letvin NL, Caulfield MJ, Bett AJ, Youil R, Kaslow DC, Emini EA. Replication-incompetent adenoviral vaccine vector elicits effective anti-immunodeficiency-virus immunity. Nature. 2002, 415:331-335. (3). Chen L, Chen D, Block E, O'Donnell M, Kufe DW, Clinton, SK.Eradication of murine bladder carcinoma by intratumor injection of a bicistronic adenoviral vector carrying cDNAs for Interleukin-12 heterodimer and its inhibition by the IL-12 p40 subunit homodimer.Journal of Immunology, 1997, 159:351-359. (4). 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