很多人不知道ACE是個啥東東， 它就是血管緊張素轉化酶。想進一步了解可以看看這個文獻：

https://www.frontiersin.org/articles/10.3389/fcimb.2020.00317/full

摘要谷歌翻譯：

The rapidly evolving pandemic of severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection worldwide cost many lives. The angiotensin converting enzyme-2 (ACE-2) has been identified as the receptor for the SARS-CoV-2 viral entry. As such, it is now receiving renewed attention as a potential target for anti-viral therapeutics. We review the physiological functions of ACE2 in the cardiovascular system and the lungs, and how the activation of ACE2/MAS/G protein coupled receptor contributes in reducing acute injury and inhibiting fibrogenesis of the lungs and protecting the cardiovascular system. In this perspective, we predominantly focus on the impact of SARS-CoV-2 infection on ACE2 and dysregulation of the protective effect of ACE2/MAS/G protein pathway vs. the deleterious effect of Renin/Angiotensin/Aldosterone. We discuss the potential effect of invasion of SARS-CoV-2 on the function of ACE2 and the loss of the protective effect of the ACE2/MAS pathway in alveolar epithelial cells and how this may amplify systemic deleterious effect of renin-angiotensin aldosterone system (RAS) in the host. Furthermore, we speculate the potential of exploiting the modulation of ACE2/MAS pathway as a natural protection of lung injury by modulation of ACE2/MAS axis or by developing targeted drugs to inhibit proteases required for viral entry.

嚴重急性呼吸系統綜合症冠狀病毒 (SARS-CoV-2) 感染在全球迅速蔓延，奪去了許多人的生命。 血管緊張素轉化酶 2 (ACE-2) 已被確定為 SARS-CoV-2 病毒進入的受體。 因此，它現在作為抗病毒治療的潛在靶點重新受到關注。 我們回顧了 ACE2 在心血管系統和肺部的生理功能，以及 ACE2/MAS/G 蛋白偶聯受體的激活如何有助於減少急性損傷和抑制肺部纖維化以及保護心血管系統。 從這個角度來看，我們主要關注 SARS-CoV-2 感染對 ACE2 的影響以及 ACE2/MAS/G 蛋白通路的保護作用與腎素/血管緊張素/醛固酮的有害作用的失調。 我們討論了 SARS-CoV-2 入侵對 ACE2 功能的潛在影響以及 ACE2/MAS 通路在肺泡上皮細胞中保護作用的喪失，以及這可能如何放大腎素-血管緊張素醛固酮系統的全身性有害作用（ RAS) 在主機中。 此外，我們推測通過調節 ACE2/MAS 軸或通過開發靶向藥物來抑制病毒進入所需的蛋白酶，可以利用 ACE2/MAS 通路的調節作為肺損傷的天然保護。